TY - JOUR
T1 - Recent progress in chemical and chemoenzymatic synthesis of carbohydrates
AU - Muthana, Saddam
AU - Cao, Hongzhi
AU - Chen, Xi
PY - 2009/12
Y1 - 2009/12
N2 - The important roles that carbohydrates play in biological processes and their potential application in diagnosis, therapeutics, and vaccine development have made them attractive synthetic targets. Despite ongoing challenges, tremendous progresses have been made in recent years for the synthesis of carbohydrates. The chemical glycosylation methods have become more sophisticated and the synthesis of oligosaccharides has become more predictable. Simplified one-pot glycosylation strategy and automated synthesis are increasingly used to obtain biologically important glycans. On the other hand, chemoenzymatic synthesis continues to be a powerful alternative for obtaining complex carbohydrates. This review highlights recent progress in chemical and chemoenzymatic synthesis of carbohydrates with a particular focus on the methods developed for the synthesis of oligosaccharides, polysaccharides, glycolipids, and glycosylated natural products.
AB - The important roles that carbohydrates play in biological processes and their potential application in diagnosis, therapeutics, and vaccine development have made them attractive synthetic targets. Despite ongoing challenges, tremendous progresses have been made in recent years for the synthesis of carbohydrates. The chemical glycosylation methods have become more sophisticated and the synthesis of oligosaccharides has become more predictable. Simplified one-pot glycosylation strategy and automated synthesis are increasingly used to obtain biologically important glycans. On the other hand, chemoenzymatic synthesis continues to be a powerful alternative for obtaining complex carbohydrates. This review highlights recent progress in chemical and chemoenzymatic synthesis of carbohydrates with a particular focus on the methods developed for the synthesis of oligosaccharides, polysaccharides, glycolipids, and glycosylated natural products.
UR - http://www.scopus.com/inward/record.url?scp=70549088023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70549088023&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2009.09.013
DO - 10.1016/j.cbpa.2009.09.013
M3 - Article
C2 - 19833544
AN - SCOPUS:70549088023
VL - 13
SP - 573
EP - 581
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
SN - 1367-5931
IS - 5-6
ER -