Recent advances in understanding phosphoinositide signaling in the nervous system [version 1; referees: 3 approved]

Research output: Contribution to journalReview article

Abstract

Polyphosphoinositides (PPIn) are essential signaling phospholipids that make remarkable contributions to the identity of all cellular membranes and signaling cascades in mammalian cells. They exert regulatory control over membrane homeostasis via selective interactions with cellular proteins at the membrane–cytoplasm interface. This review article briefly summarizes our current understanding of the key roles that PPIn play in orchestrating and regulating crucial electrical and chemical signaling events in mammalian neurons and the significant neuro-pathophysiological conditions that arise following alterations in their metabolism.

Original languageEnglish (US)
Article number278
JournalF1000Research
Volume8
DOIs
StatePublished - Jan 1 2019

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Phosphatidylinositol Phosphates
Neurology
Phosphatidylinositols
Nervous System
Membranes
Homeostasis
Neurons
Metabolism
Phospholipids
Cells
Proteins
essential 303 forte

Keywords

  • Endoplasmic reticulum
  • Ion channel
  • Membrane contact site
  • Neuron
  • Phosphatidylinositol
  • Phosphoinositide
  • Phospholipase C
  • Phospholipids
  • Plasma membrane
  • Polyphosphoinositide
  • Voltage gated Ca2+ channel
  • Voltage gated K+ channel

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Recent advances in understanding phosphoinositide signaling in the nervous system [version 1; referees: 3 approved]",
abstract = "Polyphosphoinositides (PPIn) are essential signaling phospholipids that make remarkable contributions to the identity of all cellular membranes and signaling cascades in mammalian cells. They exert regulatory control over membrane homeostasis via selective interactions with cellular proteins at the membrane–cytoplasm interface. This review article briefly summarizes our current understanding of the key roles that PPIn play in orchestrating and regulating crucial electrical and chemical signaling events in mammalian neurons and the significant neuro-pathophysiological conditions that arise following alterations in their metabolism.",
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AB - Polyphosphoinositides (PPIn) are essential signaling phospholipids that make remarkable contributions to the identity of all cellular membranes and signaling cascades in mammalian cells. They exert regulatory control over membrane homeostasis via selective interactions with cellular proteins at the membrane–cytoplasm interface. This review article briefly summarizes our current understanding of the key roles that PPIn play in orchestrating and regulating crucial electrical and chemical signaling events in mammalian neurons and the significant neuro-pathophysiological conditions that arise following alterations in their metabolism.

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KW - Phospholipids

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KW - Voltage gated Ca2+ channel

KW - Voltage gated K+ channel

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