Recent advances in multicomponent reactions for diversity-oriented synthesis

James E. Biggs-Houck, Ashkaan Younai, Jared T. Shaw

Research output: Contribution to journalArticlepeer-review

419 Scopus citations


Interest in multicomponent reactions (MCRs) has surged during the past two decades as interest in the efficient synthesis of small molecule libraries has gained prominence. MCRs fill an important niche in library synthesis by providing direct access to library compounds and by serving as starting points for Diversity-Oriented Synthesis (DOS). Recent advances in the area of MCR chemistry have included the discovery of new reactions, development of the first asymmetric catalysts, and the application of MCRs to natural products and other targets of biological interest. This review will highlight recent developments in MCRs as a rich source of molecular diversity.

Original languageEnglish (US)
Pages (from-to)371-382
Number of pages12
JournalCurrent Opinion in Chemical Biology
Issue number3
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry


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