Abstract
Laser tweezers Raman spectroscopy (LTRS), a technique that integrates optical tweezers with confocal Raman spectroscopy, is a variation of micro-Raman spectroscopy that enables the manipulation and biochemical analysis of single biological particles in suspension. This article provides an overview of the LTRS method, with an emphasis on highlighting recent advances over the past several years in the development of the technology and several new biological and biomedical applications that have been demonstrated. A perspective on the future developments of this powerful cytometric technology will also be presented.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 36-48 |
| Number of pages | 13 |
| Journal | Journal of Biophotonics |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2013 |
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Keywords
- Cytometry
- Label-free
- Laser tweezers
- Optical trapping
- Raman spectroscopy
ASJC Scopus subject areas
- Materials Science(all)
- Engineering(all)
- Physics and Astronomy(all)
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)