Recent advances in laser tweezers Raman spectroscopy (LTRS) for label-free analysis of single cells

James W Chan

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Laser tweezers Raman spectroscopy (LTRS), a technique that integrates optical tweezers with confocal Raman spectroscopy, is a variation of micro-Raman spectroscopy that enables the manipulation and biochemical analysis of single biological particles in suspension. This article provides an overview of the LTRS method, with an emphasis on highlighting recent advances over the past several years in the development of the technology and several new biological and biomedical applications that have been demonstrated. A perspective on the future developments of this powerful cytometric technology will also be presented.

Original languageEnglish (US)
Pages (from-to)36-48
Number of pages13
JournalJournal of Biophotonics
Volume6
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Cytometry
  • Label-free
  • Laser tweezers
  • Optical trapping
  • Raman spectroscopy

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)
  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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