Recanalization of infrainguinal chronic total occlusions with the crosser system: Results of the PATRIOT trial

John Laird, James Joye, Naveen Sachdev, Paul Huang, Ronald Caputo, Imran Mohiuddin, John Runyon, Tony Das

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

PURPOSE: To evaluate the angiographic and functional outcomes of the Crosser chronic total occlusion (CTO) recanalization system used to facilitate crossing of infrainguinal occlusions resistant to conventional guidewire techniques. METHODS: Eighty-five patients with a previous or concurrent failed attempt to cross a CTO using conventional guidewire techniques were enrolled at eight United States centers. Occlusions were at least 30 days old and ≤30 cm in length. Primary endpoints included advancement of the recanalization system into or through the occlusion gaining guidewire access in the distal vessel beyond the lesion, and 30-day freedom from clinical perforation requiring treatment. RESULTS: The average age of occlusion was 16 months, the mean occlusion length was 117.5 ± 84.0 mm, 55.7% had unfavorable morphology for crossing, and 75% were moderately to severely calcified. Superficial femoral artery (SFA) occlusions were most commonly treated (61.2%), followed by popliteal artery (20%), and tibioperoneal (16.5%) occlusions. The CTO was crossed and the guidewire successfully advanced into the distal true lumen in 83.5% of cases. Following adjunctive therapy, 81.2% achieved a satisfactory angiographic result (≤50% residual stenosis). At 30 days post procedure, 98.8% of patients were free from clinical perforation. CONCLUSION: Use of the Crosser CTO recanalization system facilitated crossing of guidewire-resistant, chronic, infrainguinal occlusions with minimal risk of clinically significant vessel perforation.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalJournal of Invasive Cardiology
Volume26
Issue number10
StatePublished - Oct 1 2014

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Popliteal Artery
Femoral Artery
Pathologic Constriction
Therapeutics

Keywords

  • chronic total occlusion (CTO)
  • critical limb ischemia
  • infrainguinal occlusion
  • mechanical recanalization system
  • peripheral artery disease (PAD)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Laird, J., Joye, J., Sachdev, N., Huang, P., Caputo, R., Mohiuddin, I., ... Das, T. (2014). Recanalization of infrainguinal chronic total occlusions with the crosser system: Results of the PATRIOT trial. Journal of Invasive Cardiology, 26(10), 497-504.

Recanalization of infrainguinal chronic total occlusions with the crosser system : Results of the PATRIOT trial. / Laird, John; Joye, James; Sachdev, Naveen; Huang, Paul; Caputo, Ronald; Mohiuddin, Imran; Runyon, John; Das, Tony.

In: Journal of Invasive Cardiology, Vol. 26, No. 10, 01.10.2014, p. 497-504.

Research output: Contribution to journalArticle

Laird, J, Joye, J, Sachdev, N, Huang, P, Caputo, R, Mohiuddin, I, Runyon, J & Das, T 2014, 'Recanalization of infrainguinal chronic total occlusions with the crosser system: Results of the PATRIOT trial', Journal of Invasive Cardiology, vol. 26, no. 10, pp. 497-504.
Laird J, Joye J, Sachdev N, Huang P, Caputo R, Mohiuddin I et al. Recanalization of infrainguinal chronic total occlusions with the crosser system: Results of the PATRIOT trial. Journal of Invasive Cardiology. 2014 Oct 1;26(10):497-504.
Laird, John ; Joye, James ; Sachdev, Naveen ; Huang, Paul ; Caputo, Ronald ; Mohiuddin, Imran ; Runyon, John ; Das, Tony. / Recanalization of infrainguinal chronic total occlusions with the crosser system : Results of the PATRIOT trial. In: Journal of Invasive Cardiology. 2014 ; Vol. 26, No. 10. pp. 497-504.
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