Real-time evolution of new genes by innovation, amplification, and divergence

Joakim Näsvall, Lei Sun, John R. Roth, Dan I. Andersson

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Gene duplications allow evolution of genes with new functions. Here, we describe the innovation-amplification-divergence (IAD) model in which the new function appears before duplication and functionally distinct new genes evolve under continuous selection. One example fitting this model is a preexisting parental gene in Salmonella enterica that has low levels of two distinct activities. This gene is amplified to a high copy number, and the amplified gene copies accumulate mutations that provide enzymatic specialization of different copies and faster growth. Selection maintains the initial amplification and beneficial mutant alleles but is relaxed for other less improved gene copies, allowing their loss. This rapid process, completed in fewer than 3000 generations, shows the efficacy of the IAD model and allows the study of gene evolution in real time.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalScience
Volume338
Issue number6105
DOIs
StatePublished - Oct 19 2012

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Gene Amplification
Genes
Gene Dosage
Gene Duplication
Salmonella enterica
Alleles
Mutation
Growth

ASJC Scopus subject areas

  • General

Cite this

Näsvall, J., Sun, L., Roth, J. R., & Andersson, D. I. (2012). Real-time evolution of new genes by innovation, amplification, and divergence. Science, 338(6105), 384-387. https://doi.org/10.1126/science.1226521

Real-time evolution of new genes by innovation, amplification, and divergence. / Näsvall, Joakim; Sun, Lei; Roth, John R.; Andersson, Dan I.

In: Science, Vol. 338, No. 6105, 19.10.2012, p. 384-387.

Research output: Contribution to journalArticle

Näsvall, J, Sun, L, Roth, JR & Andersson, DI 2012, 'Real-time evolution of new genes by innovation, amplification, and divergence', Science, vol. 338, no. 6105, pp. 384-387. https://doi.org/10.1126/science.1226521
Näsvall, Joakim ; Sun, Lei ; Roth, John R. ; Andersson, Dan I. / Real-time evolution of new genes by innovation, amplification, and divergence. In: Science. 2012 ; Vol. 338, No. 6105. pp. 384-387.
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