Abstract
The reactogenicity and immunogenicity of a double-strength acellular pertussis vaccine were evaluated after administration to 16 4-6-year-old children. The vaccine contained toxoided lymphocytosis-promoting factor (6.0 μg/dose), filamentous haemagglutinin (70 μg/dose), agglutinogens (1.4 μg/dose) and the 69 kDa protein (≈8.0 μg/dose). The vaccine was extremely well tolerated with few minor side effects following immunization. Significant increases in antibodies to all pertussis vaccine components were noted. In summary, this double-strength acellular pertussis vaccine, containing a very high dose of filamentous haemagglutinin, had minimal reactogenicity and was immunogenic. These findings, as well as other studies with this vaccine, indicate that filamentous haemagglutinin is not a major determinant of vaccine reactogenicity.
Original language | English (US) |
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Pages (from-to) | 614-616 |
Number of pages | 3 |
Journal | Vaccine |
Volume | 10 |
Issue number | 9 |
DOIs | |
State | Published - 1992 |
Externally published | Yes |
Keywords
- acellular vaccine
- children
- filamentous haemagglutinin
- immunogenicity
- Pertussis
- reactogenicity
ASJC Scopus subject areas
- Immunology
- Microbiology
- Virology
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)