Reactivation of Toxoplasma gondii by cytomegalovirus disease in mice: Antimicrobial activities of macrophage

Claire Pomeroy, S. Kline, M. C. Jordan, G. A. Filice

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Reactivation of Toxoplasma gondii infection often occurs concurrently with active cytomegalovirus (CMV) disease in immunocompromised patients, and CMV disease results in immunosuppression. To determine if murine CMV (MCMV) infection decreases resistance to T. gondii, mice with latent T. gondii infection were infected with MCMV. T. gondii infection reactivated, manifested primarily as pneumonia. Lung macrophages supported the growth of T. gondii before, during, and after T. gondii reactivation. Peritoneal macrophages inhibited the growth of T. gondii as pneumonia developed and became permissive as pneumonia resolved. Mice with latent T. gondii infection could survive larger doses of MCMV than could controls. Thus, MCMV infection led to reactivation of latent T. gondii infection in mice. Activation of lung macrophages, assessed by their ability to inhibit replication of T. gondii in vitro, was not associated with control of T. gondii infection.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalJournal of Infectious Diseases
Volume160
Issue number2
StatePublished - 1989
Externally publishedYes

Fingerprint

Toxoplasmosis
Toxoplasma
Cytomegalovirus
Macrophages
Pneumonia
Muromegalovirus
Lung
Macrophage Activation
Cytomegalovirus Infections
Immunocompromised Host
Peritoneal Macrophages
Growth
Immunosuppression
Infection

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Reactivation of Toxoplasma gondii by cytomegalovirus disease in mice : Antimicrobial activities of macrophage. / Pomeroy, Claire; Kline, S.; Jordan, M. C.; Filice, G. A.

In: Journal of Infectious Diseases, Vol. 160, No. 2, 1989, p. 305-311.

Research output: Contribution to journalArticle

Pomeroy, Claire ; Kline, S. ; Jordan, M. C. ; Filice, G. A. / Reactivation of Toxoplasma gondii by cytomegalovirus disease in mice : Antimicrobial activities of macrophage. In: Journal of Infectious Diseases. 1989 ; Vol. 160, No. 2. pp. 305-311.
@article{5a034ee6d50f4b3ca1d7ddc9bbeee11b,
title = "Reactivation of Toxoplasma gondii by cytomegalovirus disease in mice: Antimicrobial activities of macrophage",
abstract = "Reactivation of Toxoplasma gondii infection often occurs concurrently with active cytomegalovirus (CMV) disease in immunocompromised patients, and CMV disease results in immunosuppression. To determine if murine CMV (MCMV) infection decreases resistance to T. gondii, mice with latent T. gondii infection were infected with MCMV. T. gondii infection reactivated, manifested primarily as pneumonia. Lung macrophages supported the growth of T. gondii before, during, and after T. gondii reactivation. Peritoneal macrophages inhibited the growth of T. gondii as pneumonia developed and became permissive as pneumonia resolved. Mice with latent T. gondii infection could survive larger doses of MCMV than could controls. Thus, MCMV infection led to reactivation of latent T. gondii infection in mice. Activation of lung macrophages, assessed by their ability to inhibit replication of T. gondii in vitro, was not associated with control of T. gondii infection.",
author = "Claire Pomeroy and S. Kline and Jordan, {M. C.} and Filice, {G. A.}",
year = "1989",
language = "English (US)",
volume = "160",
pages = "305--311",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Reactivation of Toxoplasma gondii by cytomegalovirus disease in mice

T2 - Antimicrobial activities of macrophage

AU - Pomeroy, Claire

AU - Kline, S.

AU - Jordan, M. C.

AU - Filice, G. A.

PY - 1989

Y1 - 1989

N2 - Reactivation of Toxoplasma gondii infection often occurs concurrently with active cytomegalovirus (CMV) disease in immunocompromised patients, and CMV disease results in immunosuppression. To determine if murine CMV (MCMV) infection decreases resistance to T. gondii, mice with latent T. gondii infection were infected with MCMV. T. gondii infection reactivated, manifested primarily as pneumonia. Lung macrophages supported the growth of T. gondii before, during, and after T. gondii reactivation. Peritoneal macrophages inhibited the growth of T. gondii as pneumonia developed and became permissive as pneumonia resolved. Mice with latent T. gondii infection could survive larger doses of MCMV than could controls. Thus, MCMV infection led to reactivation of latent T. gondii infection in mice. Activation of lung macrophages, assessed by their ability to inhibit replication of T. gondii in vitro, was not associated with control of T. gondii infection.

AB - Reactivation of Toxoplasma gondii infection often occurs concurrently with active cytomegalovirus (CMV) disease in immunocompromised patients, and CMV disease results in immunosuppression. To determine if murine CMV (MCMV) infection decreases resistance to T. gondii, mice with latent T. gondii infection were infected with MCMV. T. gondii infection reactivated, manifested primarily as pneumonia. Lung macrophages supported the growth of T. gondii before, during, and after T. gondii reactivation. Peritoneal macrophages inhibited the growth of T. gondii as pneumonia developed and became permissive as pneumonia resolved. Mice with latent T. gondii infection could survive larger doses of MCMV than could controls. Thus, MCMV infection led to reactivation of latent T. gondii infection in mice. Activation of lung macrophages, assessed by their ability to inhibit replication of T. gondii in vitro, was not associated with control of T. gondii infection.

UR - http://www.scopus.com/inward/record.url?scp=0024315538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024315538&partnerID=8YFLogxK

M3 - Article

C2 - 2547877

AN - SCOPUS:0024315538

VL - 160

SP - 305

EP - 311

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -