TY - JOUR
T1 - Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties
AU - Lancz, Kinga
AU - Murínová, Ľubica
AU - Patayová, Henrieta
AU - Drobná, Beata
AU - Wimmerová, Soňa
AU - Šovčíková, Eva
AU - Kováč, Ján
AU - Farkašová, Dana
AU - Hertz-Picciotto, Irva
AU - Jusko, Todd A.
AU - Trnovec, Tomáš
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The aim was to characterize placental transfer of some congeners of polychlorinated biphenyls (PCBs) and to relate human in utero exposure to these pollutants to their physicochemical properties. We included into the study 1134 births during the period 2002-2003 from two highly PCB contaminated districts in eastern Slovakia. Concentrations of 15 PCB congeners (IUPAC No. 28, 52, 101, 123(+149), 118, 114, 153, 105, 138(+163), 167, 156(+171), 157, 180, 170, and 189) in umbilical cord (C) and maternal serum (M) were determined. The C/M ratios were significantly related, either positively or inversely depending on parameter, to the logarithm of partition coefficient octanol-water (KOW), to fusion enthalpy at the melting point, molecular weight, water solubility, total surface area of the molecule, solvent accessible surface area, melting point, molar volume, and molecular electronegativity distance vector. We found an inverse association between logKOW and lipid adjusted logC/M (const=1.078, b1=-0.179, p<0.001, R(2)=0.039). Parameters evaluated were interrelated except fusion enthalpy at the melting point and electron affinity vs. solubility. We discuss the possible role of cholesterol as a transplacental transporter of PCBs.
AB - The aim was to characterize placental transfer of some congeners of polychlorinated biphenyls (PCBs) and to relate human in utero exposure to these pollutants to their physicochemical properties. We included into the study 1134 births during the period 2002-2003 from two highly PCB contaminated districts in eastern Slovakia. Concentrations of 15 PCB congeners (IUPAC No. 28, 52, 101, 123(+149), 118, 114, 153, 105, 138(+163), 167, 156(+171), 157, 180, 170, and 189) in umbilical cord (C) and maternal serum (M) were determined. The C/M ratios were significantly related, either positively or inversely depending on parameter, to the logarithm of partition coefficient octanol-water (KOW), to fusion enthalpy at the melting point, molecular weight, water solubility, total surface area of the molecule, solvent accessible surface area, melting point, molar volume, and molecular electronegativity distance vector. We found an inverse association between logKOW and lipid adjusted logC/M (const=1.078, b1=-0.179, p<0.001, R(2)=0.039). Parameters evaluated were interrelated except fusion enthalpy at the melting point and electron affinity vs. solubility. We discuss the possible role of cholesterol as a transplacental transporter of PCBs.
KW - Partition coefficient octanol water
KW - Physicochemical parameters
KW - Placenta
KW - Placental transfer
KW - Polychlorinated biphenyls
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U2 - 10.1016/j.ijheh.2014.08.003
DO - 10.1016/j.ijheh.2014.08.003
M3 - Article
C2 - 25277764
AN - SCOPUS:84927693687
VL - 218
SP - 91
EP - 98
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
SN - 1438-4639
IS - 1
ER -