Abstract
Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 291-295 |
| Number of pages | 5 |
| Journal | Developmental Brain Research |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1987 |
| Externally published | Yes |
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Keywords
- Astroglia
- Endothelial cell
- Extracellular matrix
- Glutamine synthetase
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience
Cite this
Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia. / Grinspan, J. B.; Lieb, M.; Stern, J.; Rupnick, M.; Williams, S.; Pleasure, David E.
In: Developmental Brain Research, Vol. 33, No. 2, 1987, p. 291-295.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia
AU - Grinspan, J. B.
AU - Lieb, M.
AU - Stern, J.
AU - Rupnick, M.
AU - Williams, S.
AU - Pleasure, David E
PY - 1987
Y1 - 1987
N2 - Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.
AB - Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.
KW - Astroglia
KW - Endothelial cell
KW - Extracellular matrix
KW - Glutamine synthetase
UR - http://www.scopus.com/inward/record.url?scp=0023202409&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023202409&partnerID=8YFLogxK
U2 - 10.1016/0165-3806(87)90162-3
DO - 10.1016/0165-3806(87)90162-3
M3 - Article
VL - 33
SP - 291
EP - 295
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 2
ER -