Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia

J. B. Grinspan, M. Lieb, J. Stern, M. Rupnick, S. Williams, David E Pleasure

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalDevelopmental Brain Research
Volume33
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • Astroglia
  • Endothelial cell
  • Extracellular matrix
  • Glutamine synthetase

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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