Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia

J. B. Grinspan; M. Lieb; J. Stern; M. Rupnick; S. Williams; David E Pleasure

doi:10.1016/0165-3806(87)90162-3

Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia

J. B. Grinspan, M. Lieb, J. Stern, M. Rupnick, S. Williams, David E Pleasure

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.

Original language	English (US)
Pages (from-to)	291-295
Number of pages	5
Journal	Developmental Brain Research
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(87)90162-3
State	Published - 1987
Externally published	Yes

Keywords

Astroglia
Endothelial cell
Extracellular matrix
Glutamine synthetase

ASJC Scopus subject areas

Developmental Biology
Developmental Neuroscience

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10.1016/0165-3806(87)90162-3

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abstract = "Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.",

keywords = "Astroglia, Endothelial cell, Extracellular matrix, Glutamine synthetase",

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T1 - Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia

AU - Grinspan, J. B.

AU - Lieb, M.

AU - Stern, J.

AU - Rupnick, M.

AU - Williams, S.

AU - Pleasure, David E

PY - 1987

Y1 - 1987

N2 - Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.

AB - Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.

KW - Astroglia

KW - Endothelial cell

KW - Extracellular matrix

KW - Glutamine synthetase

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