Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia.

J. B. Grinspan, M. Lieb, J. Stern, M. Rupnick, S. Williams, David E Pleasure

Research output: Contribution to journalArticle

Abstract

Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalBrain Research
Volume430
Issue number2
StatePublished - Jun 1987
Externally publishedYes

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Microvessels
Astrocytes
Extracellular Matrix
Phenotype
Glutamate-Ammonia Ligase
Brain
Endothelial Cells
Conditioned Culture Medium
Epithelium

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Grinspan, J. B., Lieb, M., Stern, J., Rupnick, M., Williams, S., & Pleasure, D. E. (1987). Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia. Brain Research, 430(2), 291-295.

Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia. / Grinspan, J. B.; Lieb, M.; Stern, J.; Rupnick, M.; Williams, S.; Pleasure, David E.

In: Brain Research, Vol. 430, No. 2, 06.1987, p. 291-295.

Research output: Contribution to journalArticle

Grinspan, JB, Lieb, M, Stern, J, Rupnick, M, Williams, S & Pleasure, DE 1987, 'Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia.', Brain Research, vol. 430, no. 2, pp. 291-295.
Grinspan, J. B. ; Lieb, M. ; Stern, J. ; Rupnick, M. ; Williams, S. ; Pleasure, David E. / Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia. In: Brain Research. 1987 ; Vol. 430, No. 2. pp. 291-295.
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