Rat and human dorsal root ganglion electrical and optical signaling using the in vitro chip-based human investigational platform (ICHIP)

Erik V. Mukerjee, Heather A. Enright, Margaret W. Mcnerney, Fang Qian, Sarah Felix, Allan Chang, Nicholas O Fischer, Joanne Osburn, Sarah Baker, Elizabeth K. Wheeler, Kris Kulp, Andrea Ghetti, Paul Miller, Satinderpall Pannu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

LLNL has demonstrated simultaneous fluorescence optical imaging and electrophysiological cell signal recording of dissociated human and rat dorsal root ganglia (DRG) nerve cells using a microfabricated in vitro chip-based human investigational platform (iCHIP) device. Both human and rat DRGs on the iCHIP devices after 16 days in vitro are physiologically relevant. Neurons have been cultured and shown viable in excess of 30 days in vitro on LLNL's iCHIP platform.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages763-765
Number of pages3
ISBN (Print)9780979806476
StatePublished - 2014
Externally publishedYes
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

Keywords

  • Calcium imaging
  • Extracellular action potential
  • HDRG
  • Human on a chip
  • In vitro electrophysiology
  • Microelectrode arrays
  • Microelectrodes
  • Neuron
  • RDRG
  • Thin film electrodes

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Mukerjee, E. V., Enright, H. A., Mcnerney, M. W., Qian, F., Felix, S., Chang, A., Fischer, N. O., Osburn, J., Baker, S., Wheeler, E. K., Kulp, K., Ghetti, A., Miller, P., & Pannu, S. (2014). Rat and human dorsal root ganglion electrical and optical signaling using the in vitro chip-based human investigational platform (ICHIP). In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 763-765). Chemical and Biological Microsystems Society.