RAS SF4: Regulator of plasma membrane PI(4,5)P2

Eamonn J Dickson

doi:10.1083/jcb.201706042

RAS SF4: Regulator of plasma membrane PI(4,5)P₂

Eamonn J Dickson

Physiology and Membrane Biology

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane-cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201606047) demonstrate that RAS association domain family 4 (RAS SF4) positively influences PI(4,5)P₂ synthesis through ARF6-dependent regulation of PIP5K.

Original language	English (US)
Pages (from-to)	1879-1881
Number of pages	3
Journal	Journal of Cell Biology
Volume	216
Issue number	7
DOIs	https://doi.org/10.1083/jcb.201706042
State	Published - Jul 1 2017

ASJC Scopus subject areas

Cell Biology

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title = "RAS SF4: Regulator of plasma membrane PI(4,5)P2",

abstract = "Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane-cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201606047) demonstrate that RAS association domain family 4 (RAS SF4) positively influences PI(4,5)P2 synthesis through ARF6-dependent regulation of PIP5K.",

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