Rare tumors through the looking glass

An examination of malignant cutaneous adnexal tumors

Steve R. Martinez, Keira L. Barr, Robert J Canter

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: To identify prognostic factors related to malignant cutaneous adnexal tumors. Design: Population-based study using the Surveillance, Epidemiology, and End Results database from January 1, 1988, through December 31, 2006. Setting: Seventeen population-based cancer registries. Participants: A total of 4032 patients with malignant cutaneous adnexal tumors. Main Outcome Measures: overall survival (OS) and disease-specific survival (DSS). Results: Ten-year OS and DSS rates were 54% and 97%, respectively. Unfavorable factors for OS were increasing age (hazard ratio [HR] 1.08; 95% confidence interval [CI], 1.07-1.09; P≲λτ∀.001), distant metastases (3.26; 2.34- 4.53; P≲λτ∀.001), no surgical procedure (1.27; 1.01-1.59; P=.04), grade IV tumors (1.97; 1.18-3.28; P=.009), nodal metastases (2.19; 1.40-3.43; P=.001), and T3 tumors (1.37; 1.00-1.87; P=.04). Favorable factors for OS were a wide surgical excision (HR, 0.78; 95% CI, 0.68-0.89; P≲λτ∀.001), female sex (0.73; 0.65-0.82; P≲λτ∀.001), malignant eccrine spiradenoma (0.72; 0.53-0.99; P=.04), and histologic findings of sweat duct carcinoma (0.63; 0.44-0.90; P=.01). Unfavorable factors for DSS included N1 status (HR, 6.77; 95% CI, 2.11-21.68; P≲λτ∀.001), distant metastases (12.24; 6.03-24.85; P≲λτ∀.001), histologic findings of malignant eccrine spiradenoma (5.62; 1.25-25.34; P=.02), and no surgical procedure (2.81; 1.09-7.23; P=.03). Favorable factors for DSS included female sex (HR, 0.52; 95% CI, 0.30-0.91; P=.02). Conclusions: Five-year survival among patients with malignant cutaneous adnexal tumors is good in the absence of distant metastases. Wide resection may be preferable to less aggressive excision. The prognostic importance of lymph node metastases warrants consideration of lymph node basin staging.

Original languageEnglish (US)
Pages (from-to)1058-1062
Number of pages5
JournalArchives of Dermatology
Volume147
Issue number9
DOIs
StatePublished - Sep 2011

Fingerprint

Glass
Skin
Survival
Neoplasm Metastasis
Neoplasms
Confidence Intervals
Lymph Nodes
Sweat
Sex Ratio
Population
Registries
Epidemiology
Survival Rate
Outcome Assessment (Health Care)
Databases
Carcinoma

ASJC Scopus subject areas

  • Dermatology

Cite this

Rare tumors through the looking glass : An examination of malignant cutaneous adnexal tumors. / Martinez, Steve R.; Barr, Keira L.; Canter, Robert J.

In: Archives of Dermatology, Vol. 147, No. 9, 09.2011, p. 1058-1062.

Research output: Contribution to journalArticle

@article{7740b757384f4ad781d9352edaabba70,
title = "Rare tumors through the looking glass: An examination of malignant cutaneous adnexal tumors",
abstract = "Objective: To identify prognostic factors related to malignant cutaneous adnexal tumors. Design: Population-based study using the Surveillance, Epidemiology, and End Results database from January 1, 1988, through December 31, 2006. Setting: Seventeen population-based cancer registries. Participants: A total of 4032 patients with malignant cutaneous adnexal tumors. Main Outcome Measures: overall survival (OS) and disease-specific survival (DSS). Results: Ten-year OS and DSS rates were 54{\%} and 97{\%}, respectively. Unfavorable factors for OS were increasing age (hazard ratio [HR] 1.08; 95{\%} confidence interval [CI], 1.07-1.09; P≲λτ∀.001), distant metastases (3.26; 2.34- 4.53; P≲λτ∀.001), no surgical procedure (1.27; 1.01-1.59; P=.04), grade IV tumors (1.97; 1.18-3.28; P=.009), nodal metastases (2.19; 1.40-3.43; P=.001), and T3 tumors (1.37; 1.00-1.87; P=.04). Favorable factors for OS were a wide surgical excision (HR, 0.78; 95{\%} CI, 0.68-0.89; P≲λτ∀.001), female sex (0.73; 0.65-0.82; P≲λτ∀.001), malignant eccrine spiradenoma (0.72; 0.53-0.99; P=.04), and histologic findings of sweat duct carcinoma (0.63; 0.44-0.90; P=.01). Unfavorable factors for DSS included N1 status (HR, 6.77; 95{\%} CI, 2.11-21.68; P≲λτ∀.001), distant metastases (12.24; 6.03-24.85; P≲λτ∀.001), histologic findings of malignant eccrine spiradenoma (5.62; 1.25-25.34; P=.02), and no surgical procedure (2.81; 1.09-7.23; P=.03). Favorable factors for DSS included female sex (HR, 0.52; 95{\%} CI, 0.30-0.91; P=.02). Conclusions: Five-year survival among patients with malignant cutaneous adnexal tumors is good in the absence of distant metastases. Wide resection may be preferable to less aggressive excision. The prognostic importance of lymph node metastases warrants consideration of lymph node basin staging.",
author = "Martinez, {Steve R.} and Barr, {Keira L.} and Canter, {Robert J}",
year = "2011",
month = "9",
doi = "10.1001/archdermatol.2011.229",
language = "English (US)",
volume = "147",
pages = "1058--1062",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "9",

}

TY - JOUR

T1 - Rare tumors through the looking glass

T2 - An examination of malignant cutaneous adnexal tumors

AU - Martinez, Steve R.

AU - Barr, Keira L.

AU - Canter, Robert J

PY - 2011/9

Y1 - 2011/9

N2 - Objective: To identify prognostic factors related to malignant cutaneous adnexal tumors. Design: Population-based study using the Surveillance, Epidemiology, and End Results database from January 1, 1988, through December 31, 2006. Setting: Seventeen population-based cancer registries. Participants: A total of 4032 patients with malignant cutaneous adnexal tumors. Main Outcome Measures: overall survival (OS) and disease-specific survival (DSS). Results: Ten-year OS and DSS rates were 54% and 97%, respectively. Unfavorable factors for OS were increasing age (hazard ratio [HR] 1.08; 95% confidence interval [CI], 1.07-1.09; P≲λτ∀.001), distant metastases (3.26; 2.34- 4.53; P≲λτ∀.001), no surgical procedure (1.27; 1.01-1.59; P=.04), grade IV tumors (1.97; 1.18-3.28; P=.009), nodal metastases (2.19; 1.40-3.43; P=.001), and T3 tumors (1.37; 1.00-1.87; P=.04). Favorable factors for OS were a wide surgical excision (HR, 0.78; 95% CI, 0.68-0.89; P≲λτ∀.001), female sex (0.73; 0.65-0.82; P≲λτ∀.001), malignant eccrine spiradenoma (0.72; 0.53-0.99; P=.04), and histologic findings of sweat duct carcinoma (0.63; 0.44-0.90; P=.01). Unfavorable factors for DSS included N1 status (HR, 6.77; 95% CI, 2.11-21.68; P≲λτ∀.001), distant metastases (12.24; 6.03-24.85; P≲λτ∀.001), histologic findings of malignant eccrine spiradenoma (5.62; 1.25-25.34; P=.02), and no surgical procedure (2.81; 1.09-7.23; P=.03). Favorable factors for DSS included female sex (HR, 0.52; 95% CI, 0.30-0.91; P=.02). Conclusions: Five-year survival among patients with malignant cutaneous adnexal tumors is good in the absence of distant metastases. Wide resection may be preferable to less aggressive excision. The prognostic importance of lymph node metastases warrants consideration of lymph node basin staging.

AB - Objective: To identify prognostic factors related to malignant cutaneous adnexal tumors. Design: Population-based study using the Surveillance, Epidemiology, and End Results database from January 1, 1988, through December 31, 2006. Setting: Seventeen population-based cancer registries. Participants: A total of 4032 patients with malignant cutaneous adnexal tumors. Main Outcome Measures: overall survival (OS) and disease-specific survival (DSS). Results: Ten-year OS and DSS rates were 54% and 97%, respectively. Unfavorable factors for OS were increasing age (hazard ratio [HR] 1.08; 95% confidence interval [CI], 1.07-1.09; P≲λτ∀.001), distant metastases (3.26; 2.34- 4.53; P≲λτ∀.001), no surgical procedure (1.27; 1.01-1.59; P=.04), grade IV tumors (1.97; 1.18-3.28; P=.009), nodal metastases (2.19; 1.40-3.43; P=.001), and T3 tumors (1.37; 1.00-1.87; P=.04). Favorable factors for OS were a wide surgical excision (HR, 0.78; 95% CI, 0.68-0.89; P≲λτ∀.001), female sex (0.73; 0.65-0.82; P≲λτ∀.001), malignant eccrine spiradenoma (0.72; 0.53-0.99; P=.04), and histologic findings of sweat duct carcinoma (0.63; 0.44-0.90; P=.01). Unfavorable factors for DSS included N1 status (HR, 6.77; 95% CI, 2.11-21.68; P≲λτ∀.001), distant metastases (12.24; 6.03-24.85; P≲λτ∀.001), histologic findings of malignant eccrine spiradenoma (5.62; 1.25-25.34; P=.02), and no surgical procedure (2.81; 1.09-7.23; P=.03). Favorable factors for DSS included female sex (HR, 0.52; 95% CI, 0.30-0.91; P=.02). Conclusions: Five-year survival among patients with malignant cutaneous adnexal tumors is good in the absence of distant metastases. Wide resection may be preferable to less aggressive excision. The prognostic importance of lymph node metastases warrants consideration of lymph node basin staging.

UR - http://www.scopus.com/inward/record.url?scp=80053067703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053067703&partnerID=8YFLogxK

U2 - 10.1001/archdermatol.2011.229

DO - 10.1001/archdermatol.2011.229

M3 - Article

VL - 147

SP - 1058

EP - 1062

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 9

ER -