Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity

E. A. Price, S. L. Bourne, R. Radbourne, P. A. Lawton, J. Lamerdin, L. H. Thompson, J. E. Arrand

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

DNA repair defects might contribute both to cancer progression and to the extreme reactions to radiotherapy observed in ~5% of patients. Polymorphic microsatellites in three DNA repair genes, XRCC1, XRCC3 and XRCC5, were analyzed for possible linkage to cancer status or clinical radiosensitivity. XRCC1, 3 and 5 proteins are involved in single-strand DNA break rejoining, recombinational repair, and double-strand DNA break rejoining respectively. Mendelianly inherited microsatellite polymorphisms in these genes were analyzed in three groups: volunteers with no cancer history; radiosensitive cancer patients; cancer patients with acceptable reactions to radiotherapy. Rare heterozygous alterations in all three gene regions were found solely in the cancer subpopulation. Association testing between these rare polymorphisms and cancer status revealed a significant association for XRCC1 (P = 0.005), and XRCC3 (P = 0.004). There was also an association between these polymorphisms and clinical radiosensitivity for XRCC1 (P = 0.03), and XRCC3 (P = 0.005).

Original languageEnglish (US)
Pages (from-to)237-247
Number of pages11
JournalSomatic Cell and Molecular Genetics
Volume23
Issue number4
StatePublished - Jul 1997
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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    Price, E. A., Bourne, S. L., Radbourne, R., Lawton, P. A., Lamerdin, J., Thompson, L. H., & Arrand, J. E. (1997). Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity. Somatic Cell and Molecular Genetics, 23(4), 237-247.