Rare case of a primary non-dural central nervous system low grade B-cell lymphoma and literature review

Antonios Papanicolau-Sengos, Jessica Wang-Rodriguez, Huan You Wang, Roland R. Lee, Anna Wong, Lawrence A. Hansen, Sepi Mahooti, Hooman Rashidi

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We present a case of a 70-year-old HIV negative man with a five-year history of progressive dysnomia and new onset right extremity numbness, dysarthria, and blurry vision. On magnetic resonance imaging (MRI), an infiltrative enhancing tumor was noted. Follow up brain biopsy results revealed a small lymphocytic infiltrate with scattered plasma cells in a predominantly perivascular growth pattern. Flow-cytometric findings revealed a lambda monotypic B-cell population. The morphology and the flow cytometric findings were consistent with involvement by a low grade Bcell lymphoma. Subsequent positron emission tomography (PET) studies along with bone marrow biopsy and serum protein electrophoresis showed no evidence of systemic disease. The above findings are consistent with involvement by a non-dural extranodal marginal zone B-cell lymphoma (MZBCL) primary to the central nervous system (CNS). This is the first reported case of a primary CNS MZBCL with flow cytometric analysis. A review of literature on this rare entity is also included.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalInternational Journal of Clinical and Experimental Pathology
Volume5
Issue number1
StatePublished - Feb 13 2012

Keywords

  • Extranodal marginal zone lymphoma
  • Primary non-dural central nervous system low grade B-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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    Papanicolau-Sengos, A., Wang-Rodriguez, J., Wang, H. Y., Lee, R. R., Wong, A., Hansen, L. A., Mahooti, S., & Rashidi, H. (2012). Rare case of a primary non-dural central nervous system low grade B-cell lymphoma and literature review. International Journal of Clinical and Experimental Pathology, 5(1), 89-95.