Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF

Jennifer E. Huffman; Paul S. De Vries; Alanna C. Morrison; Maria Sabater-Lleal; Tim Kacprowski; Paul L. Auer; Jennifer A. Brody; Daniel I. Chasman; Ming Huei Chen; Xiuqing Guo; Li An Lin; Riccardo E. Marioni; Martina Müller-Nurasyid; Lisa R. Yanek; Nathan Pankratz; Megan L. Grove; Moniek P M De Maat; Mary Cushman; Kerri L. Wiggins; Lihong Qi; Bengt Sennblad; Sarah E. Harris; Ozren Polasek; Helene Riess; Fernando Rivadeneira; Lynda M. Rose; Anuj Goel; Kent D. Taylor; Alexander Teumer; André G. Uitterlinden; Dhananjay Vaidya; Jie Yao; Weihong Tang; Daniel Levy; Melanie Waldenberger; Diane M. Becker; Aaron R. Folsom; Franco Giulianini; Andreas Greinacher; Albert Hofman; Chiang Ching Huang; Charles Kooperberg; Angela Silveira; John M. Starr; Konstantin Strauch; Rona J. Strawbridge; Alan F. Wright; Barbara McKnight; Oscar H. Franco; Neil Zakai; Rasika A. Mathias; Bruce M. Psaty; Paul M. Ridker; Geoffrey H. Tofler; Uwe Völker; Hugh Watkins; Myriam Fornage; Anders Hamsten; Ian J. Deary; Eric Boerwinkle; Wolfgang Koenig; Jerome I. Rotter; Caroline Hayward; Abbas Dehghan; Alex P. Reiner; Christopher J. O'Donnell; Nicholas L. Smith

doi:10.1182/blood-2015-02-624551

Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF

Jennifer E. Huffman, Paul S. De Vries, Alanna C. Morrison, Maria Sabater-Lleal, Tim Kacprowski, Paul L. Auer, Jennifer A. Brody, Daniel I. Chasman, Ming Huei Chen, Xiuqing Guo, Li An Lin, Riccardo E. Marioni, Martina Müller-Nurasyid, Lisa R. Yanek, Nathan Pankratz, Megan L. Grove, Moniek P M De Maat, Mary Cushman, Kerri L. Wiggins, Lihong QiBengt Sennblad, Sarah E. Harris, Ozren Polasek, Helene Riess, Fernando Rivadeneira, Lynda M. Rose, Anuj Goel, Kent D. Taylor, Alexander Teumer, André G. Uitterlinden, Dhananjay Vaidya, Jie Yao, Weihong Tang, Daniel Levy, Melanie Waldenberger, Diane M. Becker, Aaron R. Folsom, Franco Giulianini, Andreas Greinacher, Albert Hofman, Chiang Ching Huang, Charles Kooperberg, Angela Silveira, John M. Starr, Konstantin Strauch, Rona J. Strawbridge, Alan F. Wright, Barbara McKnight, Oscar H. Franco, Neil Zakai, Rasika A. Mathias, Bruce M. Psaty, Paul M. Ridker, Geoffrey H. Tofler, Uwe Völker, Hugh Watkins, Myriam Fornage, Anders Hamsten, Ian J. Deary, Eric Boerwinkle, Wolfgang Koenig, Jerome I. Rotter, Caroline Hayward, Abbas Dehghan, Alex P. Reiner, Christopher J. O'Donnell, Nicholas L. Smith

Public Health Sciences

Research output: Contribution to journal › Article

32 Scopus citations

Abstract

Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor allele frequency [MAF] ≥0.01 and

Original language	English (US)
Pages (from-to)	e19-e29
Journal	Blood
Volume	126
Issue number	11
DOIs	https://doi.org/10.1182/blood-2015-02-624551
State	Published - Sep 10 2015

ASJC Scopus subject areas

Hematology
Biochemistry
Cell Biology
Immunology

Access to Document

10.1182/blood-2015-02-624551

Fingerprint Dive into the research topics of 'Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF'. Together they form a unique fingerprint.

Cite this

Huffman, J. E., De Vries, P. S., Morrison, A. C., Sabater-Lleal, M., Kacprowski, T., Auer, P. L., Brody, J. A., Chasman, D. I., Chen, M. H., Guo, X., Lin, L. A., Marioni, R. E., Müller-Nurasyid, M., Yanek, L. R., Pankratz, N., Grove, M. L., De Maat, M. P. M., Cushman, M., Wiggins, K. L., ... Smith, N. L. (2015). Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. Blood, 126(11), e19-e29. https://doi.org/10.1182/blood-2015-02-624551

Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. / Huffman, Jennifer E.; De Vries, Paul S.; Morrison, Alanna C.; Sabater-Lleal, Maria; Kacprowski, Tim; Auer, Paul L.; Brody, Jennifer A.; Chasman, Daniel I.; Chen, Ming Huei; Guo, Xiuqing; Lin, Li An; Marioni, Riccardo E.; Müller-Nurasyid, Martina; Yanek, Lisa R.; Pankratz, Nathan; Grove, Megan L.; De Maat, Moniek P M; Cushman, Mary; Wiggins, Kerri L.; Qi, Lihong; Sennblad, Bengt; Harris, Sarah E.; Polasek, Ozren; Riess, Helene; Rivadeneira, Fernando; Rose, Lynda M.; Goel, Anuj; Taylor, Kent D.; Teumer, Alexander; Uitterlinden, André G.; Vaidya, Dhananjay; Yao, Jie; Tang, Weihong; Levy, Daniel; Waldenberger, Melanie; Becker, Diane M.; Folsom, Aaron R.; Giulianini, Franco; Greinacher, Andreas; Hofman, Albert; Huang, Chiang Ching; Kooperberg, Charles; Silveira, Angela; Starr, John M.; Strauch, Konstantin; Strawbridge, Rona J.; Wright, Alan F.; McKnight, Barbara; Franco, Oscar H.; Zakai, Neil; Mathias, Rasika A.; Psaty, Bruce M.; Ridker, Paul M.; Tofler, Geoffrey H.; Völker, Uwe; Watkins, Hugh; Fornage, Myriam; Hamsten, Anders; Deary, Ian J.; Boerwinkle, Eric; Koenig, Wolfgang; Rotter, Jerome I.; Hayward, Caroline; Dehghan, Abbas; Reiner, Alex P.; O'Donnell, Christopher J.; Smith, Nicholas L.

In: Blood, Vol. 126, No. 11, 10.09.2015, p. e19-e29.

Research output: Contribution to journal › Article

Huffman, JE, De Vries, PS, Morrison, AC, Sabater-Lleal, M, Kacprowski, T, Auer, PL, Brody, JA, Chasman, DI, Chen, MH, Guo, X, Lin, LA, Marioni, RE, Müller-Nurasyid, M, Yanek, LR, Pankratz, N, Grove, ML, De Maat, MPM, Cushman, M, Wiggins, KL, Qi, L, Sennblad, B, Harris, SE, Polasek, O, Riess, H, Rivadeneira, F, Rose, LM, Goel, A, Taylor, KD, Teumer, A, Uitterlinden, AG, Vaidya, D, Yao, J, Tang, W, Levy, D, Waldenberger, M, Becker, DM, Folsom, AR, Giulianini, F, Greinacher, A, Hofman, A, Huang, CC, Kooperberg, C, Silveira, A, Starr, JM, Strauch, K, Strawbridge, RJ, Wright, AF, McKnight, B, Franco, OH, Zakai, N, Mathias, RA, Psaty, BM, Ridker, PM, Tofler, GH, Völker, U, Watkins, H, Fornage, M, Hamsten, A, Deary, IJ, Boerwinkle, E, Koenig, W, Rotter, JI, Hayward, C, Dehghan, A, Reiner, AP, O'Donnell, CJ & Smith, NL 2015, 'Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF', Blood, vol. 126, no. 11, pp. e19-e29. https://doi.org/10.1182/blood-2015-02-624551

Huffman, Jennifer E. ; De Vries, Paul S. ; Morrison, Alanna C. ; Sabater-Lleal, Maria ; Kacprowski, Tim ; Auer, Paul L. ; Brody, Jennifer A. ; Chasman, Daniel I. ; Chen, Ming Huei ; Guo, Xiuqing ; Lin, Li An ; Marioni, Riccardo E. ; Müller-Nurasyid, Martina ; Yanek, Lisa R. ; Pankratz, Nathan ; Grove, Megan L. ; De Maat, Moniek P M ; Cushman, Mary ; Wiggins, Kerri L. ; Qi, Lihong ; Sennblad, Bengt ; Harris, Sarah E. ; Polasek, Ozren ; Riess, Helene ; Rivadeneira, Fernando ; Rose, Lynda M. ; Goel, Anuj ; Taylor, Kent D. ; Teumer, Alexander ; Uitterlinden, André G. ; Vaidya, Dhananjay ; Yao, Jie ; Tang, Weihong ; Levy, Daniel ; Waldenberger, Melanie ; Becker, Diane M. ; Folsom, Aaron R. ; Giulianini, Franco ; Greinacher, Andreas ; Hofman, Albert ; Huang, Chiang Ching ; Kooperberg, Charles ; Silveira, Angela ; Starr, John M. ; Strauch, Konstantin ; Strawbridge, Rona J. ; Wright, Alan F. ; McKnight, Barbara ; Franco, Oscar H. ; Zakai, Neil ; Mathias, Rasika A. ; Psaty, Bruce M. ; Ridker, Paul M. ; Tofler, Geoffrey H. ; Völker, Uwe ; Watkins, Hugh ; Fornage, Myriam ; Hamsten, Anders ; Deary, Ian J. ; Boerwinkle, Eric ; Koenig, Wolfgang ; Rotter, Jerome I. ; Hayward, Caroline ; Dehghan, Abbas ; Reiner, Alex P. ; O'Donnell, Christopher J. ; Smith, Nicholas L. / Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF. In: Blood. 2015 ; Vol. 126, No. 11. pp. e19-e29.

@article{2b47cb627f84445fb650941e5c83996f,

title = "Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF",

abstract = "Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor allele frequency [MAF] ≥0.01 and ",

author = "Huffman, {Jennifer E.} and {De Vries}, {Paul S.} and Morrison, {Alanna C.} and Maria Sabater-Lleal and Tim Kacprowski and Auer, {Paul L.} and Brody, {Jennifer A.} and Chasman, {Daniel I.} and Chen, {Ming Huei} and Xiuqing Guo and Lin, {Li An} and Marioni, {Riccardo E.} and Martina M{\"u}ller-Nurasyid and Yanek, {Lisa R.} and Nathan Pankratz and Grove, {Megan L.} and {De Maat}, {Moniek P M} and Mary Cushman and Wiggins, {Kerri L.} and Lihong Qi and Bengt Sennblad and Harris, {Sarah E.} and Ozren Polasek and Helene Riess and Fernando Rivadeneira and Rose, {Lynda M.} and Anuj Goel and Taylor, {Kent D.} and Alexander Teumer and Uitterlinden, {Andr{\'e} G.} and Dhananjay Vaidya and Jie Yao and Weihong Tang and Daniel Levy and Melanie Waldenberger and Becker, {Diane M.} and Folsom, {Aaron R.} and Franco Giulianini and Andreas Greinacher and Albert Hofman and Huang, {Chiang Ching} and Charles Kooperberg and Angela Silveira and Starr, {John M.} and Konstantin Strauch and Strawbridge, {Rona J.} and Wright, {Alan F.} and Barbara McKnight and Franco, {Oscar H.} and Neil Zakai and Mathias, {Rasika A.} and Psaty, {Bruce M.} and Ridker, {Paul M.} and Tofler, {Geoffrey H.} and Uwe V{\"o}lker and Hugh Watkins and Myriam Fornage and Anders Hamsten and Deary, {Ian J.} and Eric Boerwinkle and Wolfgang Koenig and Rotter, {Jerome I.} and Caroline Hayward and Abbas Dehghan and Reiner, {Alex P.} and O'Donnell, {Christopher J.} and Smith, {Nicholas L.}",

year = "2015",

month = sep,

day = "10",

doi = "10.1182/blood-2015-02-624551",

language = "English (US)",

volume = "126",

pages = "e19--e29",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "11",

}

TY - JOUR

T1 - Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF

AU - Huffman, Jennifer E.

AU - De Vries, Paul S.

AU - Morrison, Alanna C.

AU - Sabater-Lleal, Maria

AU - Kacprowski, Tim

AU - Auer, Paul L.

AU - Brody, Jennifer A.

AU - Chasman, Daniel I.

AU - Chen, Ming Huei

AU - Guo, Xiuqing

AU - Lin, Li An

AU - Marioni, Riccardo E.

AU - Müller-Nurasyid, Martina

AU - Yanek, Lisa R.

AU - Pankratz, Nathan

AU - Grove, Megan L.

AU - De Maat, Moniek P M

AU - Cushman, Mary

AU - Wiggins, Kerri L.

AU - Qi, Lihong

AU - Sennblad, Bengt

AU - Harris, Sarah E.

AU - Polasek, Ozren

AU - Riess, Helene

AU - Rivadeneira, Fernando

AU - Rose, Lynda M.

AU - Goel, Anuj

AU - Taylor, Kent D.

AU - Teumer, Alexander

AU - Uitterlinden, André G.

AU - Vaidya, Dhananjay

AU - Yao, Jie

AU - Tang, Weihong

AU - Levy, Daniel

AU - Waldenberger, Melanie

AU - Becker, Diane M.

AU - Folsom, Aaron R.

AU - Giulianini, Franco

AU - Greinacher, Andreas

AU - Hofman, Albert

AU - Huang, Chiang Ching

AU - Kooperberg, Charles

AU - Silveira, Angela

AU - Starr, John M.

AU - Strauch, Konstantin

AU - Strawbridge, Rona J.

AU - Wright, Alan F.

AU - McKnight, Barbara

AU - Franco, Oscar H.

AU - Zakai, Neil

AU - Mathias, Rasika A.

AU - Psaty, Bruce M.

AU - Ridker, Paul M.

AU - Tofler, Geoffrey H.

AU - Völker, Uwe

AU - Watkins, Hugh

AU - Fornage, Myriam

AU - Hamsten, Anders

AU - Deary, Ian J.

AU - Boerwinkle, Eric

AU - Koenig, Wolfgang

AU - Rotter, Jerome I.

AU - Hayward, Caroline

AU - Dehghan, Abbas

AU - Reiner, Alex P.

AU - O'Donnell, Christopher J.

AU - Smith, Nicholas L.

PY - 2015/9/10

Y1 - 2015/9/10

N2 - Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor allele frequency [MAF] ≥0.01 and

AB - Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor allele frequency [MAF] ≥0.01 and

UR - http://www.scopus.com/inward/record.url?scp=84942364202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942364202&partnerID=8YFLogxK

U2 - 10.1182/blood-2015-02-624551

DO - 10.1182/blood-2015-02-624551

M3 - Article

C2 - 26105150

AN - SCOPUS:84942364202

VL - 126

SP - e19-e29

JO - Blood

JF - Blood

SN - 0006-4971

IS - 11

ER -