Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge

L. Jean Patterson, Mara Daltabuit-Test, Peng Xiao, Jun Zhao, William Hu, Ulrike Wille-Reece, Egidio Brocca-Cofano, V. S. Kalyanaraman, Irene Kalisz, Stephen Whitney, Eun Mi Lee, Ranajit Pal, David C. Montefiori, Satya Dandekar, Robert Seder, Mario Roederer, Roger W. Wiseman, Vanessa Hirsch, Marjorie Robert-Guroff

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIVmac251 challenges, exhibited elite control of viremia over 6.5years. They were negative for host factors associated with control of SIV infection. After a third intrarectal challenge with SIVsmE660, all controlled viremia, with one (macaque #5) maintaining undetectable viremia in blood. Acquisition was not blocked, but virus was contained in the jejunum and draining lymph nodes. Polyfunctional memory T cell responses and high-titered neutralizing and non-neutralizing serum and mucosal antibodies were present before and maintained post-challenge. The level of protection seen for animal #5 was predicted from analyses of gene transcription in jejunum 2weeks post-challenge. Macaques #7 and #9, exhibiting lower pre-challenge cellular and humoral immunity, partially controlled the SIVsmE660 challenge. Initial vaccine-induced control by macaque #5 extended to the SIVsmE660 challenge due to multiple immune mechanisms that were boosted and augmented by cryptic SIV exposure.

Original languageEnglish (US)
Pages (from-to)87-102
Number of pages16
JournalVirology
Volume411
Issue number1
DOIs
StatePublished - Mar 1 2011

Keywords

  • Elite-control
  • Memory
  • Multifaceted immunity
  • SIV
  • Vaccine
  • Virus sequestration

ASJC Scopus subject areas

  • Virology

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    Patterson, L. J., Daltabuit-Test, M., Xiao, P., Zhao, J., Hu, W., Wille-Reece, U., Brocca-Cofano, E., Kalyanaraman, V. S., Kalisz, I., Whitney, S., Lee, E. M., Pal, R., Montefiori, D. C., Dandekar, S., Seder, R., Roederer, M., Wiseman, R. W., Hirsch, V., & Robert-Guroff, M. (2011). Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge. Virology, 411(1), 87-102. https://doi.org/10.1016/j.virol.2010.12.033