TY - JOUR
T1 - Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge
AU - Patterson, L. Jean
AU - Daltabuit-Test, Mara
AU - Xiao, Peng
AU - Zhao, Jun
AU - Hu, William
AU - Wille-Reece, Ulrike
AU - Brocca-Cofano, Egidio
AU - Kalyanaraman, V. S.
AU - Kalisz, Irene
AU - Whitney, Stephen
AU - Lee, Eun Mi
AU - Pal, Ranajit
AU - Montefiori, David C.
AU - Dandekar, Satya
AU - Seder, Robert
AU - Roederer, Mario
AU - Wiseman, Roger W.
AU - Hirsch, Vanessa
AU - Robert-Guroff, Marjorie
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIVmac251 challenges, exhibited elite control of viremia over 6.5years. They were negative for host factors associated with control of SIV infection. After a third intrarectal challenge with SIVsmE660, all controlled viremia, with one (macaque #5) maintaining undetectable viremia in blood. Acquisition was not blocked, but virus was contained in the jejunum and draining lymph nodes. Polyfunctional memory T cell responses and high-titered neutralizing and non-neutralizing serum and mucosal antibodies were present before and maintained post-challenge. The level of protection seen for animal #5 was predicted from analyses of gene transcription in jejunum 2weeks post-challenge. Macaques #7 and #9, exhibiting lower pre-challenge cellular and humoral immunity, partially controlled the SIVsmE660 challenge. Initial vaccine-induced control by macaque #5 extended to the SIVsmE660 challenge due to multiple immune mechanisms that were boosted and augmented by cryptic SIV exposure.
AB - Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIVmac251 challenges, exhibited elite control of viremia over 6.5years. They were negative for host factors associated with control of SIV infection. After a third intrarectal challenge with SIVsmE660, all controlled viremia, with one (macaque #5) maintaining undetectable viremia in blood. Acquisition was not blocked, but virus was contained in the jejunum and draining lymph nodes. Polyfunctional memory T cell responses and high-titered neutralizing and non-neutralizing serum and mucosal antibodies were present before and maintained post-challenge. The level of protection seen for animal #5 was predicted from analyses of gene transcription in jejunum 2weeks post-challenge. Macaques #7 and #9, exhibiting lower pre-challenge cellular and humoral immunity, partially controlled the SIVsmE660 challenge. Initial vaccine-induced control by macaque #5 extended to the SIVsmE660 challenge due to multiple immune mechanisms that were boosted and augmented by cryptic SIV exposure.
KW - Elite-control
KW - Memory
KW - Multifaceted immunity
KW - SIV
KW - Vaccine
KW - Virus sequestration
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U2 - 10.1016/j.virol.2010.12.033
DO - 10.1016/j.virol.2010.12.033
M3 - Article
C2 - 21237474
AN - SCOPUS:79551680473
VL - 411
SP - 87
EP - 102
JO - Virology
JF - Virology
SN - 0042-6822
IS - 1
ER -