TY - JOUR
T1 - Rapid-onset dystonia-parkinsonism in a second family
AU - Brashear, A.
AU - DeLeon, D.
AU - Bressman, S. B.
AU - Thyagarajan, D.
AU - Farlow, M. R.
AU - Dobyns, W. B.
PY - 1997/4
Y1 - 1997/4
N2 - Rapid-onset dystonia-parkinsonism (RDP), first described in a large Midwestern family, is now reported in a second, apparently unrelated, family in which four individuals have this same syndrome. All four developed sudden onset of dysarthria, dysphagia, severe dystonic spasms, bradykinesia, and postural instability over less than 1 hour to a few days. Three of the four had stable limb dystonia for several years preceding the onset of combined dystonia-parkinsonism. Treatment with levodopa/carbidopa provided little benefit. We propose diagnostic criteria for RDP and further define the spectrum of this unusual disease.
AB - Rapid-onset dystonia-parkinsonism (RDP), first described in a large Midwestern family, is now reported in a second, apparently unrelated, family in which four individuals have this same syndrome. All four developed sudden onset of dysarthria, dysphagia, severe dystonic spasms, bradykinesia, and postural instability over less than 1 hour to a few days. Three of the four had stable limb dystonia for several years preceding the onset of combined dystonia-parkinsonism. Treatment with levodopa/carbidopa provided little benefit. We propose diagnostic criteria for RDP and further define the spectrum of this unusual disease.
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U2 - 10.1212/WNL.48.4.1066
DO - 10.1212/WNL.48.4.1066
M3 - Article
C2 - 9109901
AN - SCOPUS:0030950937
VL - 48
SP - 1066
EP - 1069
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 4
ER -