Rapid-onset dystonia-parkinsonism in a second family

A. Brashear, D. DeLeon, S. B. Bressman, D. Thyagarajan, M. R. Farlow, W. B. Dobyns

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Rapid-onset dystonia-parkinsonism (RDP), first described in a large Midwestern family, is now reported in a second, apparently unrelated, family in which four individuals have this same syndrome. All four developed sudden onset of dysarthria, dysphagia, severe dystonic spasms, bradykinesia, and postural instability over less than 1 hour to a few days. Three of the four had stable limb dystonia for several years preceding the onset of combined dystonia-parkinsonism. Treatment with levodopa/carbidopa provided little benefit. We propose diagnostic criteria for RDP and further define the spectrum of this unusual disease.

Original languageEnglish (US)
Pages (from-to)1066-1069
Number of pages4
JournalNeurology
Volume48
Issue number4
DOIs
StatePublished - Apr 1997
Externally publishedYes

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Dystonia
Dysarthria
Hypokinesia
Spasm
Parkinsonian Disorders
Deglutition Disorders
Dystonia 12
Therapeutics
levodopa drug combination carbidopa

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Brashear, A., DeLeon, D., Bressman, S. B., Thyagarajan, D., Farlow, M. R., & Dobyns, W. B. (1997). Rapid-onset dystonia-parkinsonism in a second family. Neurology, 48(4), 1066-1069. https://doi.org/10.1212/WNL.48.4.1066

Rapid-onset dystonia-parkinsonism in a second family. / Brashear, A.; DeLeon, D.; Bressman, S. B.; Thyagarajan, D.; Farlow, M. R.; Dobyns, W. B.

In: Neurology, Vol. 48, No. 4, 04.1997, p. 1066-1069.

Research output: Contribution to journalArticle

Brashear, A, DeLeon, D, Bressman, SB, Thyagarajan, D, Farlow, MR & Dobyns, WB 1997, 'Rapid-onset dystonia-parkinsonism in a second family', Neurology, vol. 48, no. 4, pp. 1066-1069. https://doi.org/10.1212/WNL.48.4.1066
Brashear A, DeLeon D, Bressman SB, Thyagarajan D, Farlow MR, Dobyns WB. Rapid-onset dystonia-parkinsonism in a second family. Neurology. 1997 Apr;48(4):1066-1069. https://doi.org/10.1212/WNL.48.4.1066
Brashear, A. ; DeLeon, D. ; Bressman, S. B. ; Thyagarajan, D. ; Farlow, M. R. ; Dobyns, W. B. / Rapid-onset dystonia-parkinsonism in a second family. In: Neurology. 1997 ; Vol. 48, No. 4. pp. 1066-1069.
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