Abstract
Rapid-onset dystonia-parkinsonism (RDP), first described in a large Midwestern family, is now reported in a second, apparently unrelated, family in which four individuals have this same syndrome. All four developed sudden onset of dysarthria, dysphagia, severe dystonic spasms, bradykinesia, and postural instability over less than 1 hour to a few days. Three of the four had stable limb dystonia for several years preceding the onset of combined dystonia-parkinsonism. Treatment with levodopa/carbidopa provided little benefit. We propose diagnostic criteria for RDP and further define the spectrum of this unusual disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1066-1069 |
| Number of pages | 4 |
| Journal | Neurology |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Rapid-onset dystonia-parkinsonism in a second family. / Brashear, A.; DeLeon, D.; Bressman, S. B.; Thyagarajan, D.; Farlow, M. R.; Dobyns, W. B.
In: Neurology, Vol. 48, No. 4, 04.1997, p. 1066-1069.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rapid-onset dystonia-parkinsonism in a second family
AU - Brashear, A.
AU - DeLeon, D.
AU - Bressman, S. B.
AU - Thyagarajan, D.
AU - Farlow, M. R.
AU - Dobyns, W. B.
PY - 1997/4
Y1 - 1997/4
N2 - Rapid-onset dystonia-parkinsonism (RDP), first described in a large Midwestern family, is now reported in a second, apparently unrelated, family in which four individuals have this same syndrome. All four developed sudden onset of dysarthria, dysphagia, severe dystonic spasms, bradykinesia, and postural instability over less than 1 hour to a few days. Three of the four had stable limb dystonia for several years preceding the onset of combined dystonia-parkinsonism. Treatment with levodopa/carbidopa provided little benefit. We propose diagnostic criteria for RDP and further define the spectrum of this unusual disease.
AB - Rapid-onset dystonia-parkinsonism (RDP), first described in a large Midwestern family, is now reported in a second, apparently unrelated, family in which four individuals have this same syndrome. All four developed sudden onset of dysarthria, dysphagia, severe dystonic spasms, bradykinesia, and postural instability over less than 1 hour to a few days. Three of the four had stable limb dystonia for several years preceding the onset of combined dystonia-parkinsonism. Treatment with levodopa/carbidopa provided little benefit. We propose diagnostic criteria for RDP and further define the spectrum of this unusual disease.
UR - http://www.scopus.com/inward/record.url?scp=0030950937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030950937&partnerID=8YFLogxK
U2 - 10.1212/WNL.48.4.1066
DO - 10.1212/WNL.48.4.1066
M3 - Article
C2 - 9109901
AN - SCOPUS:0030950937
VL - 48
SP - 1066
EP - 1069
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 4
ER -