Rapid-onset dystonia-parkinsonism in a second family

A. Brashear, D. DeLeon, S. B. Bressman, D. Thyagarajan, M. R. Farlow, W. B. Dobyns

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Rapid-onset dystonia-parkinsonism (RDP), first described in a large Midwestern family, is now reported in a second, apparently unrelated, family in which four individuals have this same syndrome. All four developed sudden onset of dysarthria, dysphagia, severe dystonic spasms, bradykinesia, and postural instability over less than 1 hour to a few days. Three of the four had stable limb dystonia for several years preceding the onset of combined dystonia-parkinsonism. Treatment with levodopa/carbidopa provided little benefit. We propose diagnostic criteria for RDP and further define the spectrum of this unusual disease.

Original languageEnglish (US)
Pages (from-to)1066-1069
Number of pages4
Issue number4
StatePublished - Apr 1997
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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