Rapid Inverse Planning for Pressure-Driven Drug Infusions in the Brain

Kathryn H. Rosenbluth, Alastair J. Martin, Stephan Mittermeyer, Jan Eschermann, Peter J Dickinson, Krystof S. Bankiewicz

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Infusing drugs directly into the brain is advantageous to oral or intravenous delivery for large molecules or drugs requiring high local concentrations with low off-target exposure. However, surgeons manually planning the cannula position for drug delivery in the brain face a challenging three-dimensional visualization task. This study presents an intuitive inverse-planning technique to identify the optimal placement that maximizes coverage of the target structure while minimizing the potential for leakage outside the target. The technique was retrospectively validated using intraoperative magnetic resonance imaging of infusions into the striatum of non-human primates and into a tumor in a canine model and applied prospectively to upcoming human clinical trials.

Original languageEnglish (US)
Article numbere56397
JournalPLoS One
Volume8
Issue number2
DOIs
StatePublished - Feb 15 2013

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Rosenbluth, K. H., Martin, A. J., Mittermeyer, S., Eschermann, J., Dickinson, P. J., & Bankiewicz, K. S. (2013). Rapid Inverse Planning for Pressure-Driven Drug Infusions in the Brain. PLoS One, 8(2), [e56397]. https://doi.org/10.1371/journal.pone.0056397