TY - JOUR
T1 - Rapid Inverse Planning for Pressure-Driven Drug Infusions in the Brain
AU - Rosenbluth, Kathryn H.
AU - Martin, Alastair J.
AU - Mittermeyer, Stephan
AU - Eschermann, Jan
AU - Dickinson, Peter J
AU - Bankiewicz, Krystof S.
PY - 2013/2/15
Y1 - 2013/2/15
N2 - Infusing drugs directly into the brain is advantageous to oral or intravenous delivery for large molecules or drugs requiring high local concentrations with low off-target exposure. However, surgeons manually planning the cannula position for drug delivery in the brain face a challenging three-dimensional visualization task. This study presents an intuitive inverse-planning technique to identify the optimal placement that maximizes coverage of the target structure while minimizing the potential for leakage outside the target. The technique was retrospectively validated using intraoperative magnetic resonance imaging of infusions into the striatum of non-human primates and into a tumor in a canine model and applied prospectively to upcoming human clinical trials.
AB - Infusing drugs directly into the brain is advantageous to oral or intravenous delivery for large molecules or drugs requiring high local concentrations with low off-target exposure. However, surgeons manually planning the cannula position for drug delivery in the brain face a challenging three-dimensional visualization task. This study presents an intuitive inverse-planning technique to identify the optimal placement that maximizes coverage of the target structure while minimizing the potential for leakage outside the target. The technique was retrospectively validated using intraoperative magnetic resonance imaging of infusions into the striatum of non-human primates and into a tumor in a canine model and applied prospectively to upcoming human clinical trials.
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U2 - 10.1371/journal.pone.0056397
DO - 10.1371/journal.pone.0056397
M3 - Article
C2 - 23457563
AN - SCOPUS:84874037134
VL - 8
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 2
M1 - e56397
ER -