Rapid improvement of thrombotic thrombocytopenic purpura with vincristine and plasmapheresis

Jeanna L Welborn, P. Emrick, M. Acevedo

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Many patients with thrombotic thrombocytopenia purpura (TTP) fail to respond to daily plasmapheresis and the results of alternative treatments have been inconsistent. Vincristine was given weekly with continued plasmapheresis to eight patients who were refractory to plasmapheresis, antiplatelet agents, and/or corticosteroids. A rapid response to the vincristine occurred in all eight patients in 5 days with a marked rise in the platelet count and resolution of symptoms. The results in these patients suggest that early initiation of vincristine therapy in conjunction with plasmapheresis is useful in TTP.

Original languageEnglish (US)
Pages (from-to)18-21
Number of pages4
JournalAmerican Journal of Hematology
Issue number1
StatePublished - 1990


  • adjunctive therapy
  • outcome
  • platelet count

ASJC Scopus subject areas

  • Hematology


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