Rapid improvement of thrombotic thrombocytopenic purpura with vincristine and plasmapheresis

Jeanna L Welborn, P. Emrick, M. Acevedo

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Many patients with thrombotic thrombocytopenia purpura (TTP) fail to respond to daily plasmapheresis and the results of alternative treatments have been inconsistent. Vincristine was given weekly with continued plasmapheresis to eight patients who were refractory to plasmapheresis, antiplatelet agents, and/or corticosteroids. A rapid response to the vincristine occurred in all eight patients in 5 days with a marked rise in the platelet count and resolution of symptoms. The results in these patients suggest that early initiation of vincristine therapy in conjunction with plasmapheresis is useful in TTP.

Original languageEnglish (US)
Pages (from-to)18-21
Number of pages4
JournalAmerican Journal of Hematology
Volume35
Issue number1
DOIs
StatePublished - 1990

Fingerprint

Thrombotic Thrombocytopenic Purpura
Plasmapheresis
Vincristine
Purpura
Thrombocytopenia
Platelet Aggregation Inhibitors
Platelet Count
Adrenal Cortex Hormones
Therapeutics

Keywords

  • adjunctive therapy
  • outcome
  • platelet count

ASJC Scopus subject areas

  • Hematology

Cite this

Rapid improvement of thrombotic thrombocytopenic purpura with vincristine and plasmapheresis. / Welborn, Jeanna L; Emrick, P.; Acevedo, M.

In: American Journal of Hematology, Vol. 35, No. 1, 1990, p. 18-21.

Research output: Contribution to journalArticle

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