Rapid effects of estrogens on behavior: Environmental modulation and molecular mechanisms

Sarah A. Laredo, Rosalina Villalon Landeros, Brian C. Trainor

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Estradiol can modulate neural activity and behavior via both genomic and nongenomic mechanisms. Environmental cues have a major impact on the relative importance of these signaling pathways with significant consequences for behavior. First we consider how photoperiod modulates nongenomic estrogen signaling on behavior. Intriguingly, short days permit rapid effects of estrogens on aggression in both rodents and song sparrows. This highlights the importance of considering photoperiod as a variable in laboratory research. Next we review evidence for rapid effects of estradiol on ecologically-relevant behaviors including aggression, copulation, communication, and learning. We also address the impact of endocrine disruptors on estrogen signaling, such as those found in corncob bedding used in rodent research. Finally, we examine the biochemical mechanisms that may mediate rapid estrogen action on behavior in males and females. A common theme across these topics is that the effects of estrogens on social behaviors vary across different environmental conditions.

Original languageEnglish (US)
Pages (from-to)447-458
Number of pages12
JournalFrontiers in Neuroendocrinology
Volume35
Issue number4
DOIs
StatePublished - Oct 1 2014

Keywords

  • Aggression
  • Estradiol
  • MAPK
  • Melatonin
  • Nongenomic
  • Peromyscus
  • Photoperiod

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems

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