Rapid development of HPV-mediated oropharyngeal squamous cell carcinoma in the setting of immune suppression following autologous stem cell transplantation for Hodgkin lymphoma

Joo Y. Song, Ellie Maghami, Huiqing Wu, Young S. Kim, Dennis D. Weisenburger, Alexandra Levine, Auayporn Nademanee

Research output: Contribution to journalArticle

Abstract

The patient is a 61-year-old male with a diagnosis of relapse classical Hodgkin lymphoma, treated with ABVD, ICE, and achieved remission. He underwent autologous stem cell transplantation and 3. months later found to have a PET-positive neck node concerning for relapsed disease of Hodgkin lymphoma. Biopsy proved the lesion was HPV-associated squamous cell carcinoma and not relapse Hodgkin disease. Iatrogenic immunosuppression such as bone marrow transplantation can cause substantial increase risk for viral-associated tumors and therefore tissue biopsies are necessary to make that distinction to avoid inappropriate treatment.

Original languageEnglish (US)
JournalHuman Pathology: Case Reports
DOIs
StateAccepted/In press - Jun 7 2016
Externally publishedYes

Keywords

  • Hodgkin lymphoma
  • HPV
  • Squamous cell carcinoma
  • Transplantation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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