Rapid decay of serum IgG recognizing gram-negative cell wall core antigens in neonatal calves.

V. L. Douglas, James S Cullor, J. W. Tyler, Mark Thurmond, R. B. Bushnell

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12 Scopus citations


Serum immunoglobulins of the IgG isotype recognizing common gram-negative cell core epitopes were serially measured, using a direct ELISA, on samples obtained from 20 neonatal Holstein calves. An R-mutant Escherichia coli (strain J5) was used as a plate antigen in this assay. Total serum IgG concentration was measured using radial immunodiffusion. Half-lives of core antigen-specific IgG (7.56 days) and total serum IgG (22.66 days) were dramatically different (P less than 0.0005). This may be an indication of cross-reactive consumption of core antigen-specific immunoglobulins.

Original languageEnglish (US)
Pages (from-to)1138-1140
Number of pages3
JournalAmerican Journal of Veterinary Research
Issue number7
StatePublished - Jul 1989


ASJC Scopus subject areas

  • veterinary(all)

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