Abstract
The combination of two nucleoside analogues, didanosine (2',3'- dideoxyinosine or ddI) and stavudine (2',3'-didehydro-2',3'-dideoxythymidine or d4T) was studied in a double-blind dose-ranging trial to provide information about toxicity and efficacy. The 86 patients studied were antiretroviral naive and had pretreatment CD4 cell counts between 200 and 500 cells/mm3. The combination was well tolerated, with no evidence of dose- related side effects and mini- real development of peripheral neuropathy. There was a sustained decrease in human immunodeficiency virus (HIV) viral RNA levels, which appeared greater in patients receiving a full dose of one or both compounds. A concomitant increase in CD4 cell numbers, which was sustained over 52 weeks of follow-up and which was also dose related, was observed. This combination therapy deserves further study, particularly as part of triple-drug regimens.
Original language | English (US) |
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Pages (from-to) | 89-93 |
Number of pages | 5 |
Journal | Antiviral Therapy |
Volume | 2 |
Issue number | SUPPL.3 |
State | Published - 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology