Randomized controlled trial with low-dose spiral CT for lung cancer screening: Feasibility study and preliminary results

Kavita Garg, Robert L. Keith, Tim Byers, Karen Kelly, Anne L. Kerzner, David A. Lynch, York E. Miller

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

PURPOSE: To assess the feasibility of conducting a randomized controlled trial for lung cancer screening. MATERIALS AND METHODS: Subjects are being recruited into a randomized controlled trial to undergo either low-dose spiral computed tomography (CT) or observation. Subjects are from a high-risk group with known chronic obstructive pulmonary disease and sputum atypia and a moderate-risk group randomly selected from the general population of a Veterans Affairs Medical Center. All subjects must be 50-80 years of age with 30 or more pack-years of cigarette smoking and must not have undergone chest CT during the previous 3 years. Baseline screening CT is performed with 50 mA, 120 kVp, 5-mm collimation, and a pitch of 2. CT scan interpretation and management of nodules is based on Society of Thoracic Radiology guidelines. The χ2 test for categoric data was used for statistical analysis. RESULTS: To date, 304 eligible subjects have been contacted, and 239 (79%) have agreed to participate in the trial. One hundred nineteen (88%) of the 136 subjects in the high-risk group and 120 (71%) of the 168 subjects in the moderate-risk group agreed to randomization (P < .001). To date, 190 subjects have been randomized. Of the first 92 subjects examined with CT, 22 (40%) of 55 in the high-risk group and eight (22%) of 37 in the moderate-risk group had one to six noncalcified nodules that required follow-up (P = .07). In all but three subjects, nodules were smaller than 5 mm. Two of the three larger nodules were malignancies. CONCLUSION: Findings of this study indicate that a randomized controlled trial of CT to screen for lung cancer is feasible.

Original languageEnglish (US)
Pages (from-to)506-510
Number of pages5
JournalRadiology
Volume225
Issue number2
StatePublished - Nov 1 2002
Externally publishedYes

Fingerprint

Spiral Computed Tomography
Feasibility Studies
Early Detection of Cancer
Lung Neoplasms
Randomized Controlled Trials
Tomography
Veterans
Random Allocation
Sputum
Chronic Obstructive Pulmonary Disease
Thorax
Smoking
Observation
Guidelines
Population
Neoplasms

Keywords

  • Cancer screening
  • Lung neoplasms, CT
  • Lung neoplasms, diagnosis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Garg, K., Keith, R. L., Byers, T., Kelly, K., Kerzner, A. L., Lynch, D. A., & Miller, Y. E. (2002). Randomized controlled trial with low-dose spiral CT for lung cancer screening: Feasibility study and preliminary results. Radiology, 225(2), 506-510.

Randomized controlled trial with low-dose spiral CT for lung cancer screening : Feasibility study and preliminary results. / Garg, Kavita; Keith, Robert L.; Byers, Tim; Kelly, Karen; Kerzner, Anne L.; Lynch, David A.; Miller, York E.

In: Radiology, Vol. 225, No. 2, 01.11.2002, p. 506-510.

Research output: Contribution to journalArticle

Garg, K, Keith, RL, Byers, T, Kelly, K, Kerzner, AL, Lynch, DA & Miller, YE 2002, 'Randomized controlled trial with low-dose spiral CT for lung cancer screening: Feasibility study and preliminary results', Radiology, vol. 225, no. 2, pp. 506-510.
Garg, Kavita ; Keith, Robert L. ; Byers, Tim ; Kelly, Karen ; Kerzner, Anne L. ; Lynch, David A. ; Miller, York E. / Randomized controlled trial with low-dose spiral CT for lung cancer screening : Feasibility study and preliminary results. In: Radiology. 2002 ; Vol. 225, No. 2. pp. 506-510.
@article{b61813ce41104bc4a0934d7b599dd735,
title = "Randomized controlled trial with low-dose spiral CT for lung cancer screening: Feasibility study and preliminary results",
abstract = "PURPOSE: To assess the feasibility of conducting a randomized controlled trial for lung cancer screening. MATERIALS AND METHODS: Subjects are being recruited into a randomized controlled trial to undergo either low-dose spiral computed tomography (CT) or observation. Subjects are from a high-risk group with known chronic obstructive pulmonary disease and sputum atypia and a moderate-risk group randomly selected from the general population of a Veterans Affairs Medical Center. All subjects must be 50-80 years of age with 30 or more pack-years of cigarette smoking and must not have undergone chest CT during the previous 3 years. Baseline screening CT is performed with 50 mA, 120 kVp, 5-mm collimation, and a pitch of 2. CT scan interpretation and management of nodules is based on Society of Thoracic Radiology guidelines. The χ2 test for categoric data was used for statistical analysis. RESULTS: To date, 304 eligible subjects have been contacted, and 239 (79{\%}) have agreed to participate in the trial. One hundred nineteen (88{\%}) of the 136 subjects in the high-risk group and 120 (71{\%}) of the 168 subjects in the moderate-risk group agreed to randomization (P < .001). To date, 190 subjects have been randomized. Of the first 92 subjects examined with CT, 22 (40{\%}) of 55 in the high-risk group and eight (22{\%}) of 37 in the moderate-risk group had one to six noncalcified nodules that required follow-up (P = .07). In all but three subjects, nodules were smaller than 5 mm. Two of the three larger nodules were malignancies. CONCLUSION: Findings of this study indicate that a randomized controlled trial of CT to screen for lung cancer is feasible.",
keywords = "Cancer screening, Lung neoplasms, CT, Lung neoplasms, diagnosis",
author = "Kavita Garg and Keith, {Robert L.} and Tim Byers and Karen Kelly and Kerzner, {Anne L.} and Lynch, {David A.} and Miller, {York E.}",
year = "2002",
month = "11",
day = "1",
language = "English (US)",
volume = "225",
pages = "506--510",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

TY - JOUR

T1 - Randomized controlled trial with low-dose spiral CT for lung cancer screening

T2 - Feasibility study and preliminary results

AU - Garg, Kavita

AU - Keith, Robert L.

AU - Byers, Tim

AU - Kelly, Karen

AU - Kerzner, Anne L.

AU - Lynch, David A.

AU - Miller, York E.

PY - 2002/11/1

Y1 - 2002/11/1

N2 - PURPOSE: To assess the feasibility of conducting a randomized controlled trial for lung cancer screening. MATERIALS AND METHODS: Subjects are being recruited into a randomized controlled trial to undergo either low-dose spiral computed tomography (CT) or observation. Subjects are from a high-risk group with known chronic obstructive pulmonary disease and sputum atypia and a moderate-risk group randomly selected from the general population of a Veterans Affairs Medical Center. All subjects must be 50-80 years of age with 30 or more pack-years of cigarette smoking and must not have undergone chest CT during the previous 3 years. Baseline screening CT is performed with 50 mA, 120 kVp, 5-mm collimation, and a pitch of 2. CT scan interpretation and management of nodules is based on Society of Thoracic Radiology guidelines. The χ2 test for categoric data was used for statistical analysis. RESULTS: To date, 304 eligible subjects have been contacted, and 239 (79%) have agreed to participate in the trial. One hundred nineteen (88%) of the 136 subjects in the high-risk group and 120 (71%) of the 168 subjects in the moderate-risk group agreed to randomization (P < .001). To date, 190 subjects have been randomized. Of the first 92 subjects examined with CT, 22 (40%) of 55 in the high-risk group and eight (22%) of 37 in the moderate-risk group had one to six noncalcified nodules that required follow-up (P = .07). In all but three subjects, nodules were smaller than 5 mm. Two of the three larger nodules were malignancies. CONCLUSION: Findings of this study indicate that a randomized controlled trial of CT to screen for lung cancer is feasible.

AB - PURPOSE: To assess the feasibility of conducting a randomized controlled trial for lung cancer screening. MATERIALS AND METHODS: Subjects are being recruited into a randomized controlled trial to undergo either low-dose spiral computed tomography (CT) or observation. Subjects are from a high-risk group with known chronic obstructive pulmonary disease and sputum atypia and a moderate-risk group randomly selected from the general population of a Veterans Affairs Medical Center. All subjects must be 50-80 years of age with 30 or more pack-years of cigarette smoking and must not have undergone chest CT during the previous 3 years. Baseline screening CT is performed with 50 mA, 120 kVp, 5-mm collimation, and a pitch of 2. CT scan interpretation and management of nodules is based on Society of Thoracic Radiology guidelines. The χ2 test for categoric data was used for statistical analysis. RESULTS: To date, 304 eligible subjects have been contacted, and 239 (79%) have agreed to participate in the trial. One hundred nineteen (88%) of the 136 subjects in the high-risk group and 120 (71%) of the 168 subjects in the moderate-risk group agreed to randomization (P < .001). To date, 190 subjects have been randomized. Of the first 92 subjects examined with CT, 22 (40%) of 55 in the high-risk group and eight (22%) of 37 in the moderate-risk group had one to six noncalcified nodules that required follow-up (P = .07). In all but three subjects, nodules were smaller than 5 mm. Two of the three larger nodules were malignancies. CONCLUSION: Findings of this study indicate that a randomized controlled trial of CT to screen for lung cancer is feasible.

KW - Cancer screening

KW - Lung neoplasms, CT

KW - Lung neoplasms, diagnosis

UR - http://www.scopus.com/inward/record.url?scp=0036828463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036828463&partnerID=8YFLogxK

M3 - Article

C2 - 12409588

AN - SCOPUS:0036828463

VL - 225

SP - 506

EP - 510

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -