Randomized controlled trial with low-dose spiral CT for lung cancer screening: Feasibility study and preliminary results

Kavita Garg, Robert L. Keith, Tim Byers, Karen Kelly, Anne L. Kerzner, David A. Lynch, York E. Miller

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


PURPOSE: To assess the feasibility of conducting a randomized controlled trial for lung cancer screening. MATERIALS AND METHODS: Subjects are being recruited into a randomized controlled trial to undergo either low-dose spiral computed tomography (CT) or observation. Subjects are from a high-risk group with known chronic obstructive pulmonary disease and sputum atypia and a moderate-risk group randomly selected from the general population of a Veterans Affairs Medical Center. All subjects must be 50-80 years of age with 30 or more pack-years of cigarette smoking and must not have undergone chest CT during the previous 3 years. Baseline screening CT is performed with 50 mA, 120 kVp, 5-mm collimation, and a pitch of 2. CT scan interpretation and management of nodules is based on Society of Thoracic Radiology guidelines. The χ2 test for categoric data was used for statistical analysis. RESULTS: To date, 304 eligible subjects have been contacted, and 239 (79%) have agreed to participate in the trial. One hundred nineteen (88%) of the 136 subjects in the high-risk group and 120 (71%) of the 168 subjects in the moderate-risk group agreed to randomization (P < .001). To date, 190 subjects have been randomized. Of the first 92 subjects examined with CT, 22 (40%) of 55 in the high-risk group and eight (22%) of 37 in the moderate-risk group had one to six noncalcified nodules that required follow-up (P = .07). In all but three subjects, nodules were smaller than 5 mm. Two of the three larger nodules were malignancies. CONCLUSION: Findings of this study indicate that a randomized controlled trial of CT to screen for lung cancer is feasible.

Original languageEnglish (US)
Pages (from-to)506-510
Number of pages5
Issue number2
StatePublished - Nov 1 2002
Externally publishedYes


  • Cancer screening
  • Lung neoplasms, CT
  • Lung neoplasms, diagnosis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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