Randomized, community-based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru

M. E. Penny, J. M. Peerson, R. M. Marin, A. Duran, C. F. Lanata, B. Lonnerdal, R. E. Black, K. H. Brown

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Objective: To determine whether supplemental zinc, with or without additional micronutrients, affects the severity and duration of persistent childhood diarrhea and the rate of nutritional recovery. Design: The study was a community-based, double-blind, randomized trial implemented in a shanty town in Lima, Peru. Children aged 6 to 36 months with persistent (≥ 14 days) diarrhea received daily, for 2 weeks, a placebo (group P, n = 136) or a supplement of 20 mg of zinc, either with (group Z+VM, n = 157) or without (group Z, n = 139) additional vitamins and minerals. Symptoms of illness were recorded daily; and biochemical and anthropometric assessments were completed at baseline and on day 15. Results: The treatment groups were similar at baseline with regard to the characteristics of the presenting episode, anthropometric data, and plasma zinc concentration. The children consumed, on average, 95% (group P), 94% (group Z); or 88% (group Z+VM) of the supplement (P < .001). The plasma zinc concentration did not change significantly from baseline to clay 15 in group P (4 μg/dL) but increased by 38 μg/dL in group Z and 14 μg/dL in group Z+VM. The median duration of diarrhea after starting treatment was 1 day; among children who continued to have diarrhea, there was a significant effect of treatment on diarrheal duration (P = .04, analysis of covariance). Specifically, the duration of illness was significantly reduced by 28% in children in group Z (P = .01) and by 33% in girls in group Z+VM (P = .04). There were no differences in the severity of the episode by treatment group. Conclusion: There was a significant reduction in the duration of persistent diarrhea in selected subgroups of zinc-supplemented ambulatory patients in this population.

Original languageEnglish (US)
Pages (from-to)208-217
Number of pages10
JournalJournal of Pediatrics
Volume135
Issue number2 I
StatePublished - 1999
Externally publishedYes

Fingerprint

Peru
Micronutrients
Zinc
Diarrhea
Therapeutics
Vitamins
Minerals
Placebos
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Penny, M. E., Peerson, J. M., Marin, R. M., Duran, A., Lanata, C. F., Lonnerdal, B., ... Brown, K. H. (1999). Randomized, community-based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru. Journal of Pediatrics, 135(2 I), 208-217.

Randomized, community-based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru. / Penny, M. E.; Peerson, J. M.; Marin, R. M.; Duran, A.; Lanata, C. F.; Lonnerdal, B.; Black, R. E.; Brown, K. H.

In: Journal of Pediatrics, Vol. 135, No. 2 I, 1999, p. 208-217.

Research output: Contribution to journalArticle

Penny, ME, Peerson, JM, Marin, RM, Duran, A, Lanata, CF, Lonnerdal, B, Black, RE & Brown, KH 1999, 'Randomized, community-based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru', Journal of Pediatrics, vol. 135, no. 2 I, pp. 208-217.
Penny, M. E. ; Peerson, J. M. ; Marin, R. M. ; Duran, A. ; Lanata, C. F. ; Lonnerdal, B. ; Black, R. E. ; Brown, K. H. / Randomized, community-based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru. In: Journal of Pediatrics. 1999 ; Vol. 135, No. 2 I. pp. 208-217.
@article{af28819b72ab49f7a8d71d14953b2502,
title = "Randomized, community-based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru",
abstract = "Objective: To determine whether supplemental zinc, with or without additional micronutrients, affects the severity and duration of persistent childhood diarrhea and the rate of nutritional recovery. Design: The study was a community-based, double-blind, randomized trial implemented in a shanty town in Lima, Peru. Children aged 6 to 36 months with persistent (≥ 14 days) diarrhea received daily, for 2 weeks, a placebo (group P, n = 136) or a supplement of 20 mg of zinc, either with (group Z+VM, n = 157) or without (group Z, n = 139) additional vitamins and minerals. Symptoms of illness were recorded daily; and biochemical and anthropometric assessments were completed at baseline and on day 15. Results: The treatment groups were similar at baseline with regard to the characteristics of the presenting episode, anthropometric data, and plasma zinc concentration. The children consumed, on average, 95{\%} (group P), 94{\%} (group Z); or 88{\%} (group Z+VM) of the supplement (P < .001). The plasma zinc concentration did not change significantly from baseline to clay 15 in group P (4 μg/dL) but increased by 38 μg/dL in group Z and 14 μg/dL in group Z+VM. The median duration of diarrhea after starting treatment was 1 day; among children who continued to have diarrhea, there was a significant effect of treatment on diarrheal duration (P = .04, analysis of covariance). Specifically, the duration of illness was significantly reduced by 28{\%} in children in group Z (P = .01) and by 33{\%} in girls in group Z+VM (P = .04). There were no differences in the severity of the episode by treatment group. Conclusion: There was a significant reduction in the duration of persistent diarrhea in selected subgroups of zinc-supplemented ambulatory patients in this population.",
author = "Penny, {M. E.} and Peerson, {J. M.} and Marin, {R. M.} and A. Duran and Lanata, {C. F.} and B. Lonnerdal and Black, {R. E.} and Brown, {K. H.}",
year = "1999",
language = "English (US)",
volume = "135",
pages = "208--217",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "2 I",

}

TY - JOUR

T1 - Randomized, community-based trial of the effect of zinc supplementation, with and without other micronutrients, on the duration of persistent childhood diarrhea in Lima, Peru

AU - Penny, M. E.

AU - Peerson, J. M.

AU - Marin, R. M.

AU - Duran, A.

AU - Lanata, C. F.

AU - Lonnerdal, B.

AU - Black, R. E.

AU - Brown, K. H.

PY - 1999

Y1 - 1999

N2 - Objective: To determine whether supplemental zinc, with or without additional micronutrients, affects the severity and duration of persistent childhood diarrhea and the rate of nutritional recovery. Design: The study was a community-based, double-blind, randomized trial implemented in a shanty town in Lima, Peru. Children aged 6 to 36 months with persistent (≥ 14 days) diarrhea received daily, for 2 weeks, a placebo (group P, n = 136) or a supplement of 20 mg of zinc, either with (group Z+VM, n = 157) or without (group Z, n = 139) additional vitamins and minerals. Symptoms of illness were recorded daily; and biochemical and anthropometric assessments were completed at baseline and on day 15. Results: The treatment groups were similar at baseline with regard to the characteristics of the presenting episode, anthropometric data, and plasma zinc concentration. The children consumed, on average, 95% (group P), 94% (group Z); or 88% (group Z+VM) of the supplement (P < .001). The plasma zinc concentration did not change significantly from baseline to clay 15 in group P (4 μg/dL) but increased by 38 μg/dL in group Z and 14 μg/dL in group Z+VM. The median duration of diarrhea after starting treatment was 1 day; among children who continued to have diarrhea, there was a significant effect of treatment on diarrheal duration (P = .04, analysis of covariance). Specifically, the duration of illness was significantly reduced by 28% in children in group Z (P = .01) and by 33% in girls in group Z+VM (P = .04). There were no differences in the severity of the episode by treatment group. Conclusion: There was a significant reduction in the duration of persistent diarrhea in selected subgroups of zinc-supplemented ambulatory patients in this population.

AB - Objective: To determine whether supplemental zinc, with or without additional micronutrients, affects the severity and duration of persistent childhood diarrhea and the rate of nutritional recovery. Design: The study was a community-based, double-blind, randomized trial implemented in a shanty town in Lima, Peru. Children aged 6 to 36 months with persistent (≥ 14 days) diarrhea received daily, for 2 weeks, a placebo (group P, n = 136) or a supplement of 20 mg of zinc, either with (group Z+VM, n = 157) or without (group Z, n = 139) additional vitamins and minerals. Symptoms of illness were recorded daily; and biochemical and anthropometric assessments were completed at baseline and on day 15. Results: The treatment groups were similar at baseline with regard to the characteristics of the presenting episode, anthropometric data, and plasma zinc concentration. The children consumed, on average, 95% (group P), 94% (group Z); or 88% (group Z+VM) of the supplement (P < .001). The plasma zinc concentration did not change significantly from baseline to clay 15 in group P (4 μg/dL) but increased by 38 μg/dL in group Z and 14 μg/dL in group Z+VM. The median duration of diarrhea after starting treatment was 1 day; among children who continued to have diarrhea, there was a significant effect of treatment on diarrheal duration (P = .04, analysis of covariance). Specifically, the duration of illness was significantly reduced by 28% in children in group Z (P = .01) and by 33% in girls in group Z+VM (P = .04). There were no differences in the severity of the episode by treatment group. Conclusion: There was a significant reduction in the duration of persistent diarrhea in selected subgroups of zinc-supplemented ambulatory patients in this population.

UR - http://www.scopus.com/inward/record.url?scp=0033509870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033509870&partnerID=8YFLogxK

M3 - Article

C2 - 10431116

AN - SCOPUS:0033509870

VL - 135

SP - 208

EP - 217

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 2 I

ER -