Raman spectroscopy: A diagnostic tool for detection of early malignant changes in the larynx

Nicholas Stone, Pela Stavroulaki, Catherine A. Fulljames, Martin Birchall, Hugh Barr

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations


The incidence of laryngeal cancer has risen progressively over the last 25 years. Early diagnosis and treatment of premalignant lesions of the larynx is vital to prevent progression to invasive squamous cell carcinoma. In the larynx, it has long been recognized that histological evidence of maturation abnormality is associated with a higher risk of transformation to malignancy. Currently, it is extremely difficult if not impossible for the clinician to ascertain the level of abnormality present without removing a biopsy sample and sending it for histopathological analysis. Inherent risks with this technique include damage to vocal chords and loss of speech quality as well as possible selection of unrepresentative biopsy samples. Raman spectroscopy, incorporated into an endoscopic system, has the potential to provide a real-time, non-invasive diagnostic technique able to detect biochemical changes that accompany abnormal pathology. Likely outcomes would be improved biopsy targeting and patient management by providing immediate results of tissue pathology. This paper demonstrates the capacity of near infrared Raman spectroscopy combined with statistical data analysis techniques to discriminate between normal, dysplastic and cancerous laryngeal tissue.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Number of pages9
StatePublished - 2000
Externally publishedYes
EventBiomedical Spectroscopy: Vibrational Spectroscopy and other Novel Techniques - San Jose, CA, USA
Duration: Jan 26 2000Jan 27 2000


OtherBiomedical Spectroscopy: Vibrational Spectroscopy and other Novel Techniques
CitySan Jose, CA, USA

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics


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