Raman ChemLighter: Fiber optic Raman probe imaging in combination with augmented chemical reality

Wei Yang, Abdullah S. Mondol, Clara Stiebing, Laura Marcu, Jürgen Popp, Iwan W. Schie

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Raman spectroscopy using fiber optic probe combines non-contacted and label-free molecular fingerprinting with high mechanical flexibility for biomedical, clinical and industrial applications. Inherently, fiber optic Raman probes provide information from a single point only, and the acquisition of images is not straightforward. For many applications, it is highly crucial to determine the molecular distribution and provide imaging information of the sample. Here, we propose an approach for Raman imaging using a handheld fiber optic probe, which is built around computer vision–based assessment of positional information and simultaneous acquisition of spectroscopic information. By combining this implementation with real-time data processing and analysis, it is possible to create not only fiber-based Raman imaging but also an augmented chemical reality image of the molecular distribution of the sample surface in real-time. We experimentally demonstrated that using our approach, it is possible to determine and to distinguish borders of different bimolecular compounds in a short time. Because the method can be transferred to other optical probes and other spectroscopic techniques, it is expected that the implementation will have a large impact for clinical, biomedical and industrial applications.

Original languageEnglish (US)
Article numbere201800447
JournalJournal of Biophotonics
StatePublished - Jan 1 2019


  • augmented reality
  • fiber optic probe
  • Raman imaging
  • Raman spectroscopy

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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