RAISED SERUM LEVELS OF TUMOUR NECROSIS FACTOR IN PARASITIC INFECTIONS

Philip Scuderi, Kit Lam, KennethJ Ryan, Eskild Petersen, KarenE Sterling, PaulR Finley, C. George Ray, DonaldJ Slymen, SydneyF Salmon

Research output: Contribution to journalArticle

365 Scopus citations

Abstract

In a study of serum levels of endogenous tumour necrosis factor (TNF) in healthy people and patients with neoplastic or infectious disease, only patients with kala-azar (visceral leishmaniasis) and malaria were found to have a strikingly increased frequency of raised TFN levels (66.6% and 70.0%, respectively). 7.9% of samples from both healthy subjects and patients with neoplastic disease contained measurable TNF. The discovery of elevated TNF levels in the sera of patients with parasitic diseases suggests that this cytokine may play a part in host defences against parasitic infections.

Original languageEnglish (US)
Pages (from-to)1364-1365
Number of pages2
JournalThe Lancet
Volume328
Issue number8520
DOIs
StatePublished - Dec 13 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Scuderi, P., Lam, K., Ryan, K., Petersen, E., Sterling, K., Finley, P., Ray, C. G., Slymen, D., & Salmon, S. (1986). RAISED SERUM LEVELS OF TUMOUR NECROSIS FACTOR IN PARASITIC INFECTIONS. The Lancet, 328(8520), 1364-1365. https://doi.org/10.1016/S0140-6736(86)92007-6