Rafting along the axon on Unc104 motors

Jonathan M. Scholey

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Neurotransmission depends upon the fast axonal transport of synaptic vesicle precursors by the monomeric kinesin Unc104, a motor whose mechanism of action is a topic of debate. New work suggests that the formation of lipid raft domains triggers the assembly of vesicle-bound Unc104 dimers and the concomitant activation of processive movement, facilitating efficient long-range vesicle transport.

Original languageEnglish (US)
Pages (from-to)515-516
Number of pages2
JournalDevelopmental Cell
Volume2
Issue number5
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Developmental Biology

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