Rafting along the axon on Unc104 motors

Jonathan M. Scholey

doi:10.1016/S1534-5807(02)00177-6

Rafting along the axon on Unc104 motors

Jonathan M. Scholey

Molecular and Cellular Biology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Neurotransmission depends upon the fast axonal transport of synaptic vesicle precursors by the monomeric kinesin Unc104, a motor whose mechanism of action is a topic of debate. New work suggests that the formation of lipid raft domains triggers the assembly of vesicle-bound Unc104 dimers and the concomitant activation of processive movement, facilitating efficient long-range vesicle transport.

Original language	English (US)
Pages (from-to)	515-516
Number of pages	2
Journal	Developmental Cell
Volume	2
Issue number	5
DOIs	https://doi.org/10.1016/S1534-5807(02)00177-6
State	Published - 2002

ASJC Scopus subject areas

Developmental Biology

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10.1016/S1534-5807(02)00177-6

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title = "Rafting along the axon on Unc104 motors",

abstract = "Neurotransmission depends upon the fast axonal transport of synaptic vesicle precursors by the monomeric kinesin Unc104, a motor whose mechanism of action is a topic of debate. New work suggests that the formation of lipid raft domains triggers the assembly of vesicle-bound Unc104 dimers and the concomitant activation of processive movement, facilitating efficient long-range vesicle transport.",

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AB - Neurotransmission depends upon the fast axonal transport of synaptic vesicle precursors by the monomeric kinesin Unc104, a motor whose mechanism of action is a topic of debate. New work suggests that the formation of lipid raft domains triggers the assembly of vesicle-bound Unc104 dimers and the concomitant activation of processive movement, facilitating efficient long-range vesicle transport.

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