Radiopharmaceuticals for palliation of painful osseous metastases

Howard Smith, Annu Navani, Scott M Fishman

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Bone metastases represent the most common etiology of pain for patients with advanced cancer. In the United States, the most common treatment for pain caused by bone metastases in late-stage cancer cases is external beam radiotherapy in conjunction with opioids. An alternative or adjuvant to external radiotherapy is intravenous radiopharmaceutical treatment. This review explores the pros and cons of different radiopharmaceutical options, their advantages over traditional external beam radiotherapy, and the conditions for optimal efficacy.

Original languageEnglish (US)
Pages (from-to)303-313
Number of pages11
JournalAmerican Journal of Hospice and Palliative Medicine
Issue number4
StatePublished - Jul 2004


  • 117mSn-DTPA
  • 153Sm-EDTMP
  • 186Re-HEDP
  • 32P
  • Bisphosphonates
  • Cancer pain treatment
  • Hypercalcemia
  • Orthophosphate
  • Osseous metastases
  • Phosphurous-32
  • Radiopharmaceuticals
  • Rhenium-186 hydroxyethlidene
  • Samarium-153 lexidronam
  • Strontium-89 chloride 89Sr

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Radiopharmaceuticals for palliation of painful osseous metastases'. Together they form a unique fingerprint.

Cite this