Radionuclide assessment of nitroglycerin influence on abnormal left ventricular segmental contraction in patients with coronary heart disease

A. F. Salel, D. S. Berman, Gerald L Denardo, D. T. Mason

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Noninvasive gated cardiac blood pool imaging with technetium 99m autologous erythrocytes was employed to differentiate reversible versus irreversible abnormal ventricular segmental contraction by regional wall and pump responses to sublingual nitroglycerin in 25 patients with chronic coronary heart disease. In 12 patients without ECG infarctions compared to 13 with infarctions, radioisotopic images demonstrated significantly greater percent decreases in end systolic volumes (33.8±6.7 SEM vs 18.7±4.4; P<0.05) without differences in percent reductions in end diastolic volumes (13.7±3.9 vs 11.6±6.1; NS) and thereby significantly greater percent increases in ejection fractions (9.3±1.6 vs 4.1±2.0; P<0.05). In the 22 patients with regional dyssynergy, improvement in disordered pattern and extent of localized dyssynergy following antianginal action of nitroglycerin was related to ECG absence of prior infarction. These observations demonstrate the clinical accuracy of atraumatic scintigraphy in the detection of reversible localized dyssynergy due to myocardial ischemia in coronary heart disease.

Original languageEnglish (US)
Pages (from-to)975-982
Number of pages8
JournalCirculation
Volume53
Issue number6
StatePublished - 1976

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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