Radiologist characteristics associated with interpretive performance of diagnostic mammography

Diana L Miglioretti, Rebecca Smith-Bindman, Linn Abraham, R. James Brenner, Patricia A. Carney, Erin J Aiello Bowles, Diana S M Buist, Joann G. Elmore

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Background: Extensive variability has been noted in the interpretive performance of screening mammography; however, less is known about variability in diagnostic mammography performance. Methods: We examined the performance of 123 radiologists who interpreted 35895 diagnostic mammography examinations that were obtained to evaluate a breast problem from January 1, 1996, through December 31, 2003, at 72 facilities that contribute data to the Breast Cancer Surveillance Consortium. We modeled the influence of radiologist characteristics on the sensitivity and false-positive rate of diagnostic mammography, adjusting for patient characteristics by use of a Bayesian hierarchical logistic regression model. Results: The median sensitivity was 79% (range = 27%-100%) and the median false-positive rate was 4.3% (range = 0%-16%). Radiologists in academic medical centers, compared with other radiologists, had higher sensitivity (88%, 95% confidence interval [CI] = 77% to 94%, versus 76%, 95% CI = 72% to 79%; odds ratio [OR] = 5.41, 95% Bayesian posterior credible interval [BPCI] = 1.55 to 21.51) with a smaller increase in their false-positive rates (7.8%, 95% CI = 4.8% to 12.7%, versus 4.2%, 95% CI = 3.8% to 4.7%; OR = 1.73, 95% BPCI = 1.05 to 2.67) and a borderline statistically significant improvement in accuracy (OR = 3.01, 95% BPCI = 0.97 to 12.15). Radiologists spending 20% or more of their time on breast imaging had statistically significantly higher sensitivity than those spending less time on breast imaging (80%, 95% CI = 76% to 83%, versus 70%, 95% CI = 64% to 75%; OR = 1.60, 95% BPCI = 1.05 to 2.44) with non-statistically significant increased false-positive rates (4.6%, 95% CI = 4.0% to 5.3%, versus 3.9%, 95% CI = 3.3% to 4.6%; OR = 1.17, 95% BPCI = 0.92 to 1.51). More recent training in mammography and more experience performing breast biopsy examinations were associated with a decreased threshold for recalling patients, resulting in similar statistically significant increases in both sensitivity and false-positive rates. Conclusions: We found considerable variation in the interpretive performance of diagnostic mammography across radiologists that was not explained by the characteristics of the patients whose mammograms were interpreted. This variability is concerning and likely affects many women with and without breast cancer.

Original languageEnglish (US)
Pages (from-to)1854-1863
Number of pages10
JournalJournal of the National Cancer Institute
Volume99
Issue number24
DOIs
StatePublished - Dec 2007
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Radiologist characteristics associated with interpretive performance of diagnostic mammography'. Together they form a unique fingerprint.

  • Cite this

    Miglioretti, D. L., Smith-Bindman, R., Abraham, L., Brenner, R. J., Carney, P. A., Bowles, E. J. A., Buist, D. S. M., & Elmore, J. G. (2007). Radiologist characteristics associated with interpretive performance of diagnostic mammography. Journal of the National Cancer Institute, 99(24), 1854-1863. https://doi.org/10.1093/jnci/djm238