Radioimmunotherapy

Potential as a therapeutic strategy in non-Hodgkin's lymphoma

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Lymphomas are the fifth most common malignancy in the United States and are increasing in incidence. Despite being among the most responsive malignancies to radiation and chemotherapy, the majority of patients relapse or have progressive disease. Monoclonal antibodies (MAbs) directed at cell-specific surface antigens have been useful in the diagnosis of lymphomas and, more recently, the therapeutic mouse-human chimeric MAb rituximab has demonstrated effectiveness in B cell lymphomas. Conjugating MAbs to radionuclides is a strategy for improving the efficacy of MAb lymphoma therapy by delivering radiation in close proximity to the tumour (radioimmunotherapy or RIT). In addition, the low dose rate of the delivered radiation may exert a greater antitumour activity than an equivalent dose of conventional external beam radiation. The antigenic targets for MAb therapy have included CD20, CD22, HLA-DR, and B cell idiotype. Radionuclides that have been used include iodine-131, yttrium-90, and copper-67; there are relative merits and disadvantages to each source of radiation. Clinical studies to date have focused on relapsed and refractory patients with both indolent and aggressive lymphomas, although more recent studies have included previously untreated patients with indolent lymphoma. Radioimmunoconjugate has been delivered as either single or multiple doses. Response rates have varied widely, dependent on the patient population and the response criteria. Of note, complete responses can be achieved in this typically refractory patient group. Toxicities have generally consisted of mild infusion-related nausea, fever, chills, and asthenia. Neutropenia and thrombocytopenia are the dose-limiting toxicities and have prompted the incorporation of autologous stem cell support as a means of achieving dose escalation. To date, RIT has been delivered to highly selected patients in relatively few centres with requisite equipment and specialised personnel. In addition to these requirements, cost is likely to be a barrier to wide-spread use. The combination of RIT with chemotherapy at conventional or high dose, or with biological agents is a fertile area for investigation. The potential of RIT in the treatment for lymphomas will be defined only by well designed comparative prospective clinical studies.

Original languageEnglish (US)
Pages (from-to)151-162
Number of pages12
JournalBioDrugs
Volume15
Issue number3
StatePublished - 2001

Fingerprint

Radioimmunotherapy
Non-Hodgkin's Lymphoma
Lymphoma
Radiation
Radioisotopes
Therapeutics
Monoclonal Antibodies
Immunoconjugates
Yttrium
Asthenia
Drug Therapy
Neoplasms
Chills
HLA-B Antigens
Biological Factors
B-Cell Lymphoma
HLA-DR Antigens
Surface Antigens
Neutropenia
Iodine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Immunology and Allergy
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Radioimmunotherapy : Potential as a therapeutic strategy in non-Hodgkin's lymphoma. / Wun, Theodore; Kwon, D. S.; Tuscano, Joseph.

In: BioDrugs, Vol. 15, No. 3, 2001, p. 151-162.

Research output: Contribution to journalArticle

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