Radioimmunoassay for detection of anti-oligodendrocyte antibodies

Abdolmohammad Rostami, David E Pleasure, Robert P. Lisak, Donald H. Silberberg, Oded Abramsky, S. Michael Phillips

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A solid phase radioimmunoassay (RIA) for detection and quantitation of rabbit anti-oligodendrocyte antibody has been developed using bovine oligodendroglia preparation. The assay is simple, rapid, reproducible and economical. It is approximately 150× as sensitive as immunofluorescence. Specificity has been established by using different bovine tissue antigens as substrate and absorption studies. This assays represents a potentially powerful tool for the detection and quantitation of anti-oligodendroglial antibodies and oligodendroglial antigens in serum and CSF of man and experimental animals.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalNeuroscience Letters
Volume23
Issue number2
DOIs
StatePublished - May 6 1981
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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