Radical resection combined with liver transplantation for foregut tumors

D. G. Farmer, A. Shaked, J. O. Colonna, K. M. Olthoff, O. Jurim, Steven D Colquhoun, J. M. Millis, R. W. Busuttil

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Between February 1984 and July 1992, six adults with advanced pancreatic adenocarcinoma (n = 1), pancreatic neuroendocrine tumor (n = 2), and cholangiocarcinoma (n = 3) underwent radical foregut resections (n = 3) or radical pancreaticoduodenectomy (n = 3) combined with liver transplantation. The major postoperative complications included diarrhea (n = 4), pancreaticojejunostomy leak (n = 3), infection (n = 7), malnutrition (n = 3), refractory ascites (n = 2), and late hepatic artery thrombosis (n = 1). Tumor recurrence occurred in one patient. The actuarial survival for the group is 82 per cent at 1 year and 55 per cent at 2 years. The results demonstrate that radical pancreaticoduodenectomy/foregut resections combined with liver transplantation offer potential surgical cure of malignancies involving these organs. However, the procedure is formidable, with frequent complications.

Original languageEnglish (US)
Pages (from-to)806-812
Number of pages7
JournalAmerican Surgeon
Volume59
Issue number12
StatePublished - Dec 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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    Farmer, D. G., Shaked, A., Colonna, J. O., Olthoff, K. M., Jurim, O., Colquhoun, S. D., Millis, J. M., & Busuttil, R. W. (1993). Radical resection combined with liver transplantation for foregut tumors. American Surgeon, 59(12), 806-812.