Radical resection combined with liver transplantation for foregut tumors

D. G. Farmer, A. Shaked, J. O. Colonna, K. M. Olthoff, O. Jurim, Steven D Colquhoun, J. M. Millis, R. W. Busuttil

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Between February 1984 and July 1992, six adults with advanced pancreatic adenocarcinoma (n = 1), pancreatic neuroendocrine tumor (n = 2), and cholangiocarcinoma (n = 3) underwent radical foregut resections (n = 3) or radical pancreaticoduodenectomy (n = 3) combined with liver transplantation. The major postoperative complications included diarrhea (n = 4), pancreaticojejunostomy leak (n = 3), infection (n = 7), malnutrition (n = 3), refractory ascites (n = 2), and late hepatic artery thrombosis (n = 1). Tumor recurrence occurred in one patient. The actuarial survival for the group is 82 per cent at 1 year and 55 per cent at 2 years. The results demonstrate that radical pancreaticoduodenectomy/foregut resections combined with liver transplantation offer potential surgical cure of malignancies involving these organs. However, the procedure is formidable, with frequent complications.

Original languageEnglish (US)
Pages (from-to)806-812
Number of pages7
JournalAmerican Surgeon
Volume59
Issue number12
StatePublished - Dec 1 1993
Externally publishedYes

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Pancreaticoduodenectomy
Liver Transplantation
Pancreaticojejunostomy
Neuroendocrine Tumors
Cholangiocarcinoma
Hepatic Artery
Ascites
Malnutrition
Diarrhea
Neoplasms
Adenocarcinoma
Thrombosis
Recurrence
Survival
Infection

ASJC Scopus subject areas

  • Surgery

Cite this

Farmer, D. G., Shaked, A., Colonna, J. O., Olthoff, K. M., Jurim, O., Colquhoun, S. D., ... Busuttil, R. W. (1993). Radical resection combined with liver transplantation for foregut tumors. American Surgeon, 59(12), 806-812.

Radical resection combined with liver transplantation for foregut tumors. / Farmer, D. G.; Shaked, A.; Colonna, J. O.; Olthoff, K. M.; Jurim, O.; Colquhoun, Steven D; Millis, J. M.; Busuttil, R. W.

In: American Surgeon, Vol. 59, No. 12, 01.12.1993, p. 806-812.

Research output: Contribution to journalArticle

Farmer, DG, Shaked, A, Colonna, JO, Olthoff, KM, Jurim, O, Colquhoun, SD, Millis, JM & Busuttil, RW 1993, 'Radical resection combined with liver transplantation for foregut tumors', American Surgeon, vol. 59, no. 12, pp. 806-812.
Farmer DG, Shaked A, Colonna JO, Olthoff KM, Jurim O, Colquhoun SD et al. Radical resection combined with liver transplantation for foregut tumors. American Surgeon. 1993 Dec 1;59(12):806-812.
Farmer, D. G. ; Shaked, A. ; Colonna, J. O. ; Olthoff, K. M. ; Jurim, O. ; Colquhoun, Steven D ; Millis, J. M. ; Busuttil, R. W. / Radical resection combined with liver transplantation for foregut tumors. In: American Surgeon. 1993 ; Vol. 59, No. 12. pp. 806-812.
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