Radiation induced vertebral osteosarcoma following treatment of an intradural extramedullary spinal cord tumor in a dog

Peter J Dickinson, Margaret C. Mc Entee, David Lipsitz, Michael K Keel, Richard A Lecouteur

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A 2-year-old neutered female Rottweiler diagnosed with an intradural extramedullary spinal cord tumor at T12-T13 was successfully treated with cytoreductive surgery followed by Cobalt 60 teletherapy. The dog was euthanised 5-and-a-half years later following diagnosis of an osteosarcoma involving the L1 and L2 vertebrae. Evidence of the initial tumor was not present at necropsy. The vertebral neoplasm fulfilled all of the accepted criteria for a radiation induced tumor. It was concluded that adjunctive irradiation should be considered for treatment of intradural extramedullary tumors of young dogs when total surgical resection is not possible. Although tumor induction is a rare late effect of radiation therapy, the risk of this occurrence should be considered when irradiating young animals. Radiation induced tumors in dogs have been associated with coarse fractionation schemes, or when large intraoperative doses have been administered. A lower dose per fraction, e.g., 3 Gy/fraction or less, is advisable when irradiating young dogs or any dog in which the life expectancy is 3-5 or more years after irradiation.

Original languageEnglish (US)
Pages (from-to)463-470
Number of pages8
JournalVeterinary Radiology and Ultrasound
Volume42
Issue number5
DOIs
StatePublished - Sep 2001

Keywords

  • Cobalt-60 teletherapy
  • Intradural extramedullary tumor
  • Nephroblastoma
  • Osteosarcoma
  • Radiation induced tumor

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'Radiation induced vertebral osteosarcoma following treatment of an intradural extramedullary spinal cord tumor in a dog'. Together they form a unique fingerprint.

  • Cite this