Radiation induced vertebral osteosarcoma following treatment of an intradural extramedullary spinal cord tumor in a dog

Peter J Dickinson, Margaret C. Mc Entee, David Lipsitz, Michael K Keel, Richard A Lecouteur

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 2-year-old neutered female Rottweiler diagnosed with an intradural extramedullary spinal cord tumor at T12-T13 was successfully treated with cytoreductive surgery followed by Cobalt 60 teletherapy. The dog was euthanised 5-and-a-half years later following diagnosis of an osteosarcoma involving the L1 and L2 vertebrae. Evidence of the initial tumor was not present at necropsy. The vertebral neoplasm fulfilled all of the accepted criteria for a radiation induced tumor. It was concluded that adjunctive irradiation should be considered for treatment of intradural extramedullary tumors of young dogs when total surgical resection is not possible. Although tumor induction is a rare late effect of radiation therapy, the risk of this occurrence should be considered when irradiating young animals. Radiation induced tumors in dogs have been associated with coarse fractionation schemes, or when large intraoperative doses have been administered. A lower dose per fraction, e.g., 3 Gy/fraction or less, is advisable when irradiating young dogs or any dog in which the life expectancy is 3-5 or more years after irradiation.

Original languageEnglish (US)
Pages (from-to)463-470
Number of pages8
JournalVeterinary Radiology and Ultrasound
Volume42
Issue number5
DOIs
StatePublished - Sep 2001

Fingerprint

Spinal Cord Neoplasms
osteosarcoma
Osteosarcoma
spinal cord
Dogs
Radiation
neoplasms
dogs
Neoplasms
Therapeutics
irradiation
Delayed Diagnosis
Rottweiler
Life Expectancy
Cobalt
young animals
radiotherapy
resection
cobalt
dosage

Keywords

  • Cobalt-60 teletherapy
  • Intradural extramedullary tumor
  • Nephroblastoma
  • Osteosarcoma
  • Radiation induced tumor

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Radiation induced vertebral osteosarcoma following treatment of an intradural extramedullary spinal cord tumor in a dog",
abstract = "A 2-year-old neutered female Rottweiler diagnosed with an intradural extramedullary spinal cord tumor at T12-T13 was successfully treated with cytoreductive surgery followed by Cobalt 60 teletherapy. The dog was euthanised 5-and-a-half years later following diagnosis of an osteosarcoma involving the L1 and L2 vertebrae. Evidence of the initial tumor was not present at necropsy. The vertebral neoplasm fulfilled all of the accepted criteria for a radiation induced tumor. It was concluded that adjunctive irradiation should be considered for treatment of intradural extramedullary tumors of young dogs when total surgical resection is not possible. Although tumor induction is a rare late effect of radiation therapy, the risk of this occurrence should be considered when irradiating young animals. Radiation induced tumors in dogs have been associated with coarse fractionation schemes, or when large intraoperative doses have been administered. A lower dose per fraction, e.g., 3 Gy/fraction or less, is advisable when irradiating young dogs or any dog in which the life expectancy is 3-5 or more years after irradiation.",
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AU - Lecouteur, Richard A

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