Radiation damping in modern NMR experiments: Progress and challenges

Viswanathan V Krishnan, Nagarajan Murali

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


An overview of radiation damping (RD) with an historic perspective is studied by revisiting the phenomenon's impact on the quality of the spectra of samples in aqueous solutions obtained using high field NMR spectrometers. The classical description of RD based on the Bloch-Maxwell equation has presented and solved by numerical integration methods. The ultimate goal of obtaining high resolution, accurate structures of biomolecules in solution depends on obtaining high quality NMR data. Some of the techniques to suppress RD include simple pre-saturation technique of the water signal, using multiple excitation pulses, in combination with pulsed field gradients. Radiation damping is difficult to control during the course of a multiple pulse experiment since the water spins undergo the same set of pulses as that of the sample protons. It is inevitable that RD will affect the spectrum of molecules in solvents containing a high concentration of protons.

Original languageEnglish (US)
Pages (from-to)41-57
Number of pages17
JournalProgress in Nuclear Magnetic Resonance Spectroscopy
StatePublished - Jan 2013


  • Biomolecules
  • Bloch equations
  • Nuclear magnetic resonance
  • Radiation damping
  • Water suppression

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Nuclear and High Energy Physics
  • Materials Science(all)
  • Biochemistry


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