Abstract
Radiation-controlled focal pharmacology is a method using intermediate-dose radiation of a portion of the brain to break down the blood-brain barrier (BBB) followed by the administration of a drug which does not cross the normal BBB but which has a desired pharmacologic effect when it does cross the BBB. Therefore, the drug affects only the radiated portion of the brain. Cats with alumina-cobalt chronic epileptic foci were given intravenous γ-aminobutyric acid (GABA) with no suppression of their EEG-recorded, computer-analyzed epileptic spike frequency. When the focus received 6,000 rad of Bragg peak proton radiation, there was no significant change in spike frequency. Then, however, when GABA was again given, there was dramatic suppression of spike frequency, reaching a peak of 87% suppression at 9 days postradiation. The efficacy of GABA used in radiation-controlled focal pharmacology in the 7- to 9-day postradiation period was demonstrated with a confidence of p < 0.01.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 153-159 |
| Number of pages | 7 |
| Journal | Epilepsia |
| Volume | 22 |
| Issue number | 2 |
| State | Published - 1981 |
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ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Radiation-controlled focal pharmacology in the therapy of experimental epilepsy. / Remler, M. P.; Marcussen, W.
In: Epilepsia, Vol. 22, No. 2, 1981, p. 153-159.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiation-controlled focal pharmacology in the therapy of experimental epilepsy
AU - Remler, M. P.
AU - Marcussen, W.
PY - 1981
Y1 - 1981
N2 - Radiation-controlled focal pharmacology is a method using intermediate-dose radiation of a portion of the brain to break down the blood-brain barrier (BBB) followed by the administration of a drug which does not cross the normal BBB but which has a desired pharmacologic effect when it does cross the BBB. Therefore, the drug affects only the radiated portion of the brain. Cats with alumina-cobalt chronic epileptic foci were given intravenous γ-aminobutyric acid (GABA) with no suppression of their EEG-recorded, computer-analyzed epileptic spike frequency. When the focus received 6,000 rad of Bragg peak proton radiation, there was no significant change in spike frequency. Then, however, when GABA was again given, there was dramatic suppression of spike frequency, reaching a peak of 87% suppression at 9 days postradiation. The efficacy of GABA used in radiation-controlled focal pharmacology in the 7- to 9-day postradiation period was demonstrated with a confidence of p < 0.01.
AB - Radiation-controlled focal pharmacology is a method using intermediate-dose radiation of a portion of the brain to break down the blood-brain barrier (BBB) followed by the administration of a drug which does not cross the normal BBB but which has a desired pharmacologic effect when it does cross the BBB. Therefore, the drug affects only the radiated portion of the brain. Cats with alumina-cobalt chronic epileptic foci were given intravenous γ-aminobutyric acid (GABA) with no suppression of their EEG-recorded, computer-analyzed epileptic spike frequency. When the focus received 6,000 rad of Bragg peak proton radiation, there was no significant change in spike frequency. Then, however, when GABA was again given, there was dramatic suppression of spike frequency, reaching a peak of 87% suppression at 9 days postradiation. The efficacy of GABA used in radiation-controlled focal pharmacology in the 7- to 9-day postradiation period was demonstrated with a confidence of p < 0.01.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019512705&partnerID=8YFLogxK
M3 - Article
C2 - 6781892
AN - SCOPUS:0019512705
VL - 22
SP - 153
EP - 159
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 2
ER -