Abstract
Background: Depressive symptoms are predictive of multiple degenerative diseases in older age adults. However, the association of depressive symptoms with onset and progression of disability have not been studied. Methods: In a cohort of community-dwelling, older black and white adults, 5,446 initially nondisabled subjects were followed annually for disability between 2000 and 2008. Depressive symptoms were assessed at baseline using a summary measure of 10-item version of the Center for Epidemiologic Survey-Depressive symptoms scale. The disability outcome was based on a summary measure of 13 basic and instrumental activities of daily living, and analyzed using a two-part regression model for onset and progression of disability. Results: During follow-up, 44% of blacks and 35% of whites reported onset of disability. After adjusting for confounders, depressive symptoms were associated with increased odds of disability onset in blacks (odds ratio = 1.12, 95% confdence interval, 1.07-1.18) and whites (odds ratio = 1.21, 95% confdence interval, 1.08-1.36). The odds of disability onset associated with depressive symptoms also increased significantly over time in whites (odds ratio = 1.06, 95% confdence interval, 1.04-1.09), but not in blacks. In addition, depressive symptoms were associated with an increasing rate of progression of disability in whites (rate ratio = 1.08, 95% confdence interval, 1.06-1.09), but not in blacks. Conclusions: Depressive symptoms increased the risk of onset of disability in blacks and whites. This risk tended to increase over time only among whites. A similar race-specific pattern was observed for time-dependent changes due to depressive symptoms in the rate of progression in disability after onset.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 215-222 |
| Number of pages | 8 |
| Journal | Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
| Volume | 69 A |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 17 2014 |
| Externally published | Yes |
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Keywords
- Activities of daily living
- Depressive symptoms
- Instrumental activities of daily living
- Onset of disability
- Progression of disability
- Racial/ethnic differences
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology
Cite this
Racial differences on association of depressive symptoms with combined basic and instrumental activities of daily living. / Rajan, Kumar; Barnes, Lisa L.; Wilson, Robert S.; Evans, Denis A.; De Leon, Carlos F.Mendes.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 69 A, No. 2, 17.03.2014, p. 215-222.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Racial differences on association of depressive symptoms with combined basic and instrumental activities of daily living
AU - Rajan, Kumar
AU - Barnes, Lisa L.
AU - Wilson, Robert S.
AU - Evans, Denis A.
AU - De Leon, Carlos F.Mendes
PY - 2014/3/17
Y1 - 2014/3/17
N2 - Background: Depressive symptoms are predictive of multiple degenerative diseases in older age adults. However, the association of depressive symptoms with onset and progression of disability have not been studied. Methods: In a cohort of community-dwelling, older black and white adults, 5,446 initially nondisabled subjects were followed annually for disability between 2000 and 2008. Depressive symptoms were assessed at baseline using a summary measure of 10-item version of the Center for Epidemiologic Survey-Depressive symptoms scale. The disability outcome was based on a summary measure of 13 basic and instrumental activities of daily living, and analyzed using a two-part regression model for onset and progression of disability. Results: During follow-up, 44% of blacks and 35% of whites reported onset of disability. After adjusting for confounders, depressive symptoms were associated with increased odds of disability onset in blacks (odds ratio = 1.12, 95% confdence interval, 1.07-1.18) and whites (odds ratio = 1.21, 95% confdence interval, 1.08-1.36). The odds of disability onset associated with depressive symptoms also increased significantly over time in whites (odds ratio = 1.06, 95% confdence interval, 1.04-1.09), but not in blacks. In addition, depressive symptoms were associated with an increasing rate of progression of disability in whites (rate ratio = 1.08, 95% confdence interval, 1.06-1.09), but not in blacks. Conclusions: Depressive symptoms increased the risk of onset of disability in blacks and whites. This risk tended to increase over time only among whites. A similar race-specific pattern was observed for time-dependent changes due to depressive symptoms in the rate of progression in disability after onset.
AB - Background: Depressive symptoms are predictive of multiple degenerative diseases in older age adults. However, the association of depressive symptoms with onset and progression of disability have not been studied. Methods: In a cohort of community-dwelling, older black and white adults, 5,446 initially nondisabled subjects were followed annually for disability between 2000 and 2008. Depressive symptoms were assessed at baseline using a summary measure of 10-item version of the Center for Epidemiologic Survey-Depressive symptoms scale. The disability outcome was based on a summary measure of 13 basic and instrumental activities of daily living, and analyzed using a two-part regression model for onset and progression of disability. Results: During follow-up, 44% of blacks and 35% of whites reported onset of disability. After adjusting for confounders, depressive symptoms were associated with increased odds of disability onset in blacks (odds ratio = 1.12, 95% confdence interval, 1.07-1.18) and whites (odds ratio = 1.21, 95% confdence interval, 1.08-1.36). The odds of disability onset associated with depressive symptoms also increased significantly over time in whites (odds ratio = 1.06, 95% confdence interval, 1.04-1.09), but not in blacks. In addition, depressive symptoms were associated with an increasing rate of progression of disability in whites (rate ratio = 1.08, 95% confdence interval, 1.06-1.09), but not in blacks. Conclusions: Depressive symptoms increased the risk of onset of disability in blacks and whites. This risk tended to increase over time only among whites. A similar race-specific pattern was observed for time-dependent changes due to depressive symptoms in the rate of progression in disability after onset.
KW - Activities of daily living
KW - Depressive symptoms
KW - Instrumental activities of daily living
KW - Onset of disability
KW - Progression of disability
KW - Racial/ethnic differences
UR - http://www.scopus.com/inward/record.url?scp=84896797864&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896797864&partnerID=8YFLogxK
U2 - 10.1093/gerona/glt074
DO - 10.1093/gerona/glt074
M3 - Article
C2 - 23723430
AN - SCOPUS:84896797864
VL - 69 A
SP - 215
EP - 222
JO - The journals of gerontology. Series A, Biological sciences and medical sciences
JF - The journals of gerontology. Series A, Biological sciences and medical sciences
SN - 1079-5006
IS - 2
ER -