Rab small GTPase emerges as a regulator of TOR complex 2

Hisashi Tatebe, Kazuhiro Shiozaki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In diverse eukaryotic species from yeast to human, TOR (Target Of Rapamycin) protein kinase operates in signaling pathways that link extracellular stimuli to the control of cell growth and metabolism. TOR kinase functions in two distinct protein complexes, TOR complex 1 (TORC1) and 2 (TORC2). While TORC1 is known to be under the control of the Ras-like small GTPase Rheb, our knowledge about TORC2 regulation is very limited. We thus set out to identify TORC2 activators through genetic approaches in the fission yeast Schizosaccharomyces pombe. Here we briefly review our study that has identified a Rab-family GTPase, Ryh1 and its GEF (guanine nucleotide exchange factor) as positive regulators of TORC2 signaling in S. pombe. Considering the evolutionary conservation of the TOR pathways, it is conceivable that Rabfamily GTPases also play a role in the regulation of human TORC2 in cellular proliferation and insulin signaling.

Original languageEnglish (US)
JournalSmall GTPases
Volume1
Issue number3
StatePublished - Nov 2010

Fingerprint

rab GTP-Binding Proteins
Monomeric GTP-Binding Proteins
Sirolimus
Schizosaccharomyces
GTP Phosphohydrolases
Yeast
Guanine Nucleotide Exchange Factors
TOR Serine-Threonine Kinases
Cell growth
Metabolism
Protein Kinases
Conservation
Phosphotransferases
mechanistic target of rapamycin complex 1
TOR complex 2
Insulin
Yeasts
Cell Proliferation
Growth
Proteins

Keywords

  • Akt
  • Fission yeast
  • Gad8
  • Phosphorylation
  • Rab6
  • RabGTPase
  • Ryh1
  • Schizosaccharomyces pombe
  • TOR

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Rab small GTPase emerges as a regulator of TOR complex 2. / Tatebe, Hisashi; Shiozaki, Kazuhiro.

In: Small GTPases, Vol. 1, No. 3, 11.2010.

Research output: Contribution to journalArticle

Tatebe, H & Shiozaki, K 2010, 'Rab small GTPase emerges as a regulator of TOR complex 2', Small GTPases, vol. 1, no. 3.
Tatebe, Hisashi ; Shiozaki, Kazuhiro. / Rab small GTPase emerges as a regulator of TOR complex 2. In: Small GTPases. 2010 ; Vol. 1, No. 3.
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