Abstract
R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Fortythree patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4853-4855 |
| Number of pages | 3 |
| Journal | Blood |
| Volume | 113 |
| Issue number | 20 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Hematology
- Biochemistry
- Cell Biology
- Immunology
Cite this
R2* magnetic resonance imaging of the liver in patients with iron overload. / Hankins, Jane S.; McCarville, M. Beth; Loeffler, Ralf B.; Smeltzer, Matthew P.; Onciu, Mihaela; Hoffer, Fredric A.; Li, Chin-Shang; Wang, Winfred C.; Ware, Russell E.; Hillenbrand, Claudia M.
In: Blood, Vol. 113, No. 20, 2009, p. 4853-4855.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - R2* magnetic resonance imaging of the liver in patients with iron overload
AU - Hankins, Jane S.
AU - McCarville, M. Beth
AU - Loeffler, Ralf B.
AU - Smeltzer, Matthew P.
AU - Onciu, Mihaela
AU - Hoffer, Fredric A.
AU - Li, Chin-Shang
AU - Wang, Winfred C.
AU - Ware, Russell E.
AU - Hillenbrand, Claudia M.
PY - 2009
Y1 - 2009
N2 - R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Fortythree patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038.
AB - R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Fortythree patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038.
UR - http://www.scopus.com/inward/record.url?scp=66549115170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66549115170&partnerID=8YFLogxK
U2 - 10.1182/blood-2008-12-191643
DO - 10.1182/blood-2008-12-191643
M3 - Article
C2 - 19264677
AN - SCOPUS:66549115170
VL - 113
SP - 4853
EP - 4855
JO - Blood
JF - Blood
SN - 0006-4971
IS - 20
ER -