R2* magnetic resonance imaging of the liver in patients with iron overload

Jane S. Hankins, M. Beth McCarville, Ralf B. Loeffler, Matthew P. Smeltzer, Mihaela Onciu, Fredric A. Hoffer, Chin-Shang Li, Winfred C. Wang, Russell E. Ware, Claudia M. Hillenbrand

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Fortythree patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038.

Original languageEnglish (US)
Pages (from-to)4853-4855
Number of pages3
JournalBlood
Volume113
Issue number20
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Iron Overload
Magnetic resonance
Liver
Iron
Magnetic Resonance Imaging
Imaging techniques
Ferritins
Biopsy
beta-Thalassemia
Sickle Cell Anemia
Bone
Bone Marrow
Weights and Measures
Serum

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Hankins, J. S., McCarville, M. B., Loeffler, R. B., Smeltzer, M. P., Onciu, M., Hoffer, F. A., ... Hillenbrand, C. M. (2009). R2* magnetic resonance imaging of the liver in patients with iron overload. Blood, 113(20), 4853-4855. https://doi.org/10.1182/blood-2008-12-191643

R2* magnetic resonance imaging of the liver in patients with iron overload. / Hankins, Jane S.; McCarville, M. Beth; Loeffler, Ralf B.; Smeltzer, Matthew P.; Onciu, Mihaela; Hoffer, Fredric A.; Li, Chin-Shang; Wang, Winfred C.; Ware, Russell E.; Hillenbrand, Claudia M.

In: Blood, Vol. 113, No. 20, 2009, p. 4853-4855.

Research output: Contribution to journalArticle

Hankins, JS, McCarville, MB, Loeffler, RB, Smeltzer, MP, Onciu, M, Hoffer, FA, Li, C-S, Wang, WC, Ware, RE & Hillenbrand, CM 2009, 'R2* magnetic resonance imaging of the liver in patients with iron overload', Blood, vol. 113, no. 20, pp. 4853-4855. https://doi.org/10.1182/blood-2008-12-191643
Hankins JS, McCarville MB, Loeffler RB, Smeltzer MP, Onciu M, Hoffer FA et al. R2* magnetic resonance imaging of the liver in patients with iron overload. Blood. 2009;113(20):4853-4855. https://doi.org/10.1182/blood-2008-12-191643
Hankins, Jane S. ; McCarville, M. Beth ; Loeffler, Ralf B. ; Smeltzer, Matthew P. ; Onciu, Mihaela ; Hoffer, Fredric A. ; Li, Chin-Shang ; Wang, Winfred C. ; Ware, Russell E. ; Hillenbrand, Claudia M. / R2* magnetic resonance imaging of the liver in patients with iron overload. In: Blood. 2009 ; Vol. 113, No. 20. pp. 4853-4855.
@article{37bb26485ddb4d1b85ca543145cd1885,
title = "R2* magnetic resonance imaging of the liver in patients with iron overload",
abstract = "R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Fortythree patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038.",
author = "Hankins, {Jane S.} and McCarville, {M. Beth} and Loeffler, {Ralf B.} and Smeltzer, {Matthew P.} and Mihaela Onciu and Hoffer, {Fredric A.} and Chin-Shang Li and Wang, {Winfred C.} and Ware, {Russell E.} and Hillenbrand, {Claudia M.}",
year = "2009",
doi = "10.1182/blood-2008-12-191643",
language = "English (US)",
volume = "113",
pages = "4853--4855",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "20",

}

TY - JOUR

T1 - R2* magnetic resonance imaging of the liver in patients with iron overload

AU - Hankins, Jane S.

AU - McCarville, M. Beth

AU - Loeffler, Ralf B.

AU - Smeltzer, Matthew P.

AU - Onciu, Mihaela

AU - Hoffer, Fredric A.

AU - Li, Chin-Shang

AU - Wang, Winfred C.

AU - Ware, Russell E.

AU - Hillenbrand, Claudia M.

PY - 2009

Y1 - 2009

N2 - R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Fortythree patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038.

AB - R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Fortythree patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038.

UR - http://www.scopus.com/inward/record.url?scp=66549115170&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66549115170&partnerID=8YFLogxK

U2 - 10.1182/blood-2008-12-191643

DO - 10.1182/blood-2008-12-191643

M3 - Article

C2 - 19264677

AN - SCOPUS:66549115170

VL - 113

SP - 4853

EP - 4855

JO - Blood

JF - Blood

SN - 0006-4971

IS - 20

ER -