Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice

Richard W. Hyman, Susan Frank, Craig H Warden, Aaron Daluiski, Renu Heller, Aldons J. Lusis

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the phenotype of susceptibility to diet-induced atherosclerosis in the mouse, we have studied four quantitative traits: area of aortic fatty streaks and serum concentrations of high-density lipoprotein-bound cholesterol (HDL-cholesterol), apolipoprotein A-I, and apolipoprotein A-II (apo A-II). QTL analysis revealed a significant locus on chromosome 1 distal impacting serum apo A-II concentration on a high-fat diet and serum HDL-cholesterol concentration on a chow diet. This locus is presumably Apoa-2, the structural gene for apo A-II. QTL analysis of aortic fatty streaks failed to reveal a significant locus.

Original languageEnglish (US)
Pages (from-to)397-407
Number of pages11
JournalBiochemical Genetics
Volume32
Issue number11-12
DOIs
StatePublished - Dec 1994

Keywords

  • aortic fatty streaks
  • apolipoproteins
  • quantitative trait locus analysis
  • recombinant inbred mice

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

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