Quantitative temporal lobe differences: Autism distinguished from controls using classification and regression tree analysis

E. Shannon Neeley, Erin D. Bigler, Lori Krasny, Sally J Ozonoff, William McMahon, Janet E. Lainhart

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The temporal lobe is thought to be abnormal in autism, yet standard volumetric analyses are often unrevealing when age, sex, IQ, and head size are controlled. Quantification of temporal lobe structures were obtained in male subjects with autism and controls, where subjects with head circumference (HC) defined macrocephaly were excluded, so that volume differences were not just related to the higher prevalence of macrocephaly in autism. Various statistical methods were applied to the analysis including a classification and regression tree (CART) method, a non-parametric technique that helps define patterns of relationships that may be meaningful in distinguishing temporal lobe differences between subjects with autism and age and IQ matched controls. Subjects with autism were also compared to a separate control group with reading disorder (RD), with the prediction that the temporal lobe morphometric analysis of the reading disorder controls would be more similar to that of the autism group. The CART method yielded a high specificity in classifying autism subjects from controls based on the relationship between the volume of the left fusiform gyrus (LFG) gray and white matter, the right temporal stem (RTS) and the right inferior temporal gyrus gray matter (RITG-GM). Reading disordered individuals were more similar to subjects with autism. Simple size differences did not distinguish the groups. These findings demonstrate different relationships within temporal lobe structures that distinguish subjects with autism from controls. Results are discussed in terms of pathological connectivity within the temporal lobe as it relates to autism.

Original languageEnglish (US)
Pages (from-to)389-399
Number of pages11
JournalBrain and Development
Volume29
Issue number7
DOIs
StatePublished - Aug 2007

Fingerprint

Temporal Lobe
Autistic Disorder
Regression Analysis
Megalencephaly
Dyslexia
Head
Reading
Control Groups

Keywords

  • Autism
  • CART analysis
  • MRI
  • Temporal lobe

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Quantitative temporal lobe differences : Autism distinguished from controls using classification and regression tree analysis. / Shannon Neeley, E.; Bigler, Erin D.; Krasny, Lori; Ozonoff, Sally J; McMahon, William; Lainhart, Janet E.

In: Brain and Development, Vol. 29, No. 7, 08.2007, p. 389-399.

Research output: Contribution to journalArticle

Shannon Neeley, E. ; Bigler, Erin D. ; Krasny, Lori ; Ozonoff, Sally J ; McMahon, William ; Lainhart, Janet E. / Quantitative temporal lobe differences : Autism distinguished from controls using classification and regression tree analysis. In: Brain and Development. 2007 ; Vol. 29, No. 7. pp. 389-399.
@article{a875a27bd01a401e96cba4d76d265da5,
title = "Quantitative temporal lobe differences: Autism distinguished from controls using classification and regression tree analysis",
abstract = "The temporal lobe is thought to be abnormal in autism, yet standard volumetric analyses are often unrevealing when age, sex, IQ, and head size are controlled. Quantification of temporal lobe structures were obtained in male subjects with autism and controls, where subjects with head circumference (HC) defined macrocephaly were excluded, so that volume differences were not just related to the higher prevalence of macrocephaly in autism. Various statistical methods were applied to the analysis including a classification and regression tree (CART) method, a non-parametric technique that helps define patterns of relationships that may be meaningful in distinguishing temporal lobe differences between subjects with autism and age and IQ matched controls. Subjects with autism were also compared to a separate control group with reading disorder (RD), with the prediction that the temporal lobe morphometric analysis of the reading disorder controls would be more similar to that of the autism group. The CART method yielded a high specificity in classifying autism subjects from controls based on the relationship between the volume of the left fusiform gyrus (LFG) gray and white matter, the right temporal stem (RTS) and the right inferior temporal gyrus gray matter (RITG-GM). Reading disordered individuals were more similar to subjects with autism. Simple size differences did not distinguish the groups. These findings demonstrate different relationships within temporal lobe structures that distinguish subjects with autism from controls. Results are discussed in terms of pathological connectivity within the temporal lobe as it relates to autism.",
keywords = "Autism, CART analysis, MRI, Temporal lobe",
author = "{Shannon Neeley}, E. and Bigler, {Erin D.} and Lori Krasny and Ozonoff, {Sally J} and William McMahon and Lainhart, {Janet E.}",
year = "2007",
month = "8",
doi = "10.1016/j.braindev.2006.11.006",
language = "English (US)",
volume = "29",
pages = "389--399",
journal = "Brain and Development",
issn = "0387-7604",
publisher = "Elsevier",
number = "7",

}

TY - JOUR

T1 - Quantitative temporal lobe differences

T2 - Autism distinguished from controls using classification and regression tree analysis

AU - Shannon Neeley, E.

AU - Bigler, Erin D.

AU - Krasny, Lori

AU - Ozonoff, Sally J

AU - McMahon, William

AU - Lainhart, Janet E.

PY - 2007/8

Y1 - 2007/8

N2 - The temporal lobe is thought to be abnormal in autism, yet standard volumetric analyses are often unrevealing when age, sex, IQ, and head size are controlled. Quantification of temporal lobe structures were obtained in male subjects with autism and controls, where subjects with head circumference (HC) defined macrocephaly were excluded, so that volume differences were not just related to the higher prevalence of macrocephaly in autism. Various statistical methods were applied to the analysis including a classification and regression tree (CART) method, a non-parametric technique that helps define patterns of relationships that may be meaningful in distinguishing temporal lobe differences between subjects with autism and age and IQ matched controls. Subjects with autism were also compared to a separate control group with reading disorder (RD), with the prediction that the temporal lobe morphometric analysis of the reading disorder controls would be more similar to that of the autism group. The CART method yielded a high specificity in classifying autism subjects from controls based on the relationship between the volume of the left fusiform gyrus (LFG) gray and white matter, the right temporal stem (RTS) and the right inferior temporal gyrus gray matter (RITG-GM). Reading disordered individuals were more similar to subjects with autism. Simple size differences did not distinguish the groups. These findings demonstrate different relationships within temporal lobe structures that distinguish subjects with autism from controls. Results are discussed in terms of pathological connectivity within the temporal lobe as it relates to autism.

AB - The temporal lobe is thought to be abnormal in autism, yet standard volumetric analyses are often unrevealing when age, sex, IQ, and head size are controlled. Quantification of temporal lobe structures were obtained in male subjects with autism and controls, where subjects with head circumference (HC) defined macrocephaly were excluded, so that volume differences were not just related to the higher prevalence of macrocephaly in autism. Various statistical methods were applied to the analysis including a classification and regression tree (CART) method, a non-parametric technique that helps define patterns of relationships that may be meaningful in distinguishing temporal lobe differences between subjects with autism and age and IQ matched controls. Subjects with autism were also compared to a separate control group with reading disorder (RD), with the prediction that the temporal lobe morphometric analysis of the reading disorder controls would be more similar to that of the autism group. The CART method yielded a high specificity in classifying autism subjects from controls based on the relationship between the volume of the left fusiform gyrus (LFG) gray and white matter, the right temporal stem (RTS) and the right inferior temporal gyrus gray matter (RITG-GM). Reading disordered individuals were more similar to subjects with autism. Simple size differences did not distinguish the groups. These findings demonstrate different relationships within temporal lobe structures that distinguish subjects with autism from controls. Results are discussed in terms of pathological connectivity within the temporal lobe as it relates to autism.

KW - Autism

KW - CART analysis

KW - MRI

KW - Temporal lobe

UR - http://www.scopus.com/inward/record.url?scp=34248569902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248569902&partnerID=8YFLogxK

U2 - 10.1016/j.braindev.2006.11.006

DO - 10.1016/j.braindev.2006.11.006

M3 - Article

C2 - 17204387

AN - SCOPUS:34248569902

VL - 29

SP - 389

EP - 399

JO - Brain and Development

JF - Brain and Development

SN - 0387-7604

IS - 7

ER -