Abstract
The temporal lobe is thought to be abnormal in autism, yet standard volumetric analyses are often unrevealing when age, sex, IQ, and head size are controlled. Quantification of temporal lobe structures were obtained in male subjects with autism and controls, where subjects with head circumference (HC) defined macrocephaly were excluded, so that volume differences were not just related to the higher prevalence of macrocephaly in autism. Various statistical methods were applied to the analysis including a classification and regression tree (CART) method, a non-parametric technique that helps define patterns of relationships that may be meaningful in distinguishing temporal lobe differences between subjects with autism and age and IQ matched controls. Subjects with autism were also compared to a separate control group with reading disorder (RD), with the prediction that the temporal lobe morphometric analysis of the reading disorder controls would be more similar to that of the autism group. The CART method yielded a high specificity in classifying autism subjects from controls based on the relationship between the volume of the left fusiform gyrus (LFG) gray and white matter, the right temporal stem (RTS) and the right inferior temporal gyrus gray matter (RITG-GM). Reading disordered individuals were more similar to subjects with autism. Simple size differences did not distinguish the groups. These findings demonstrate different relationships within temporal lobe structures that distinguish subjects with autism from controls. Results are discussed in terms of pathological connectivity within the temporal lobe as it relates to autism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 389-399 |
| Number of pages | 11 |
| Journal | Brain and Development |
| Volume | 29 |
| Issue number | 7 |
| DOIs | |
| State | Published - Aug 2007 |
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Keywords
- Autism
- CART analysis
- MRI
- Temporal lobe
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
- Neurology
Cite this
Quantitative temporal lobe differences : Autism distinguished from controls using classification and regression tree analysis. / Shannon Neeley, E.; Bigler, Erin D.; Krasny, Lori; Ozonoff, Sally J; McMahon, William; Lainhart, Janet E.
In: Brain and Development, Vol. 29, No. 7, 08.2007, p. 389-399.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantitative temporal lobe differences
T2 - Autism distinguished from controls using classification and regression tree analysis
AU - Shannon Neeley, E.
AU - Bigler, Erin D.
AU - Krasny, Lori
AU - Ozonoff, Sally J
AU - McMahon, William
AU - Lainhart, Janet E.
PY - 2007/8
Y1 - 2007/8
N2 - The temporal lobe is thought to be abnormal in autism, yet standard volumetric analyses are often unrevealing when age, sex, IQ, and head size are controlled. Quantification of temporal lobe structures were obtained in male subjects with autism and controls, where subjects with head circumference (HC) defined macrocephaly were excluded, so that volume differences were not just related to the higher prevalence of macrocephaly in autism. Various statistical methods were applied to the analysis including a classification and regression tree (CART) method, a non-parametric technique that helps define patterns of relationships that may be meaningful in distinguishing temporal lobe differences between subjects with autism and age and IQ matched controls. Subjects with autism were also compared to a separate control group with reading disorder (RD), with the prediction that the temporal lobe morphometric analysis of the reading disorder controls would be more similar to that of the autism group. The CART method yielded a high specificity in classifying autism subjects from controls based on the relationship between the volume of the left fusiform gyrus (LFG) gray and white matter, the right temporal stem (RTS) and the right inferior temporal gyrus gray matter (RITG-GM). Reading disordered individuals were more similar to subjects with autism. Simple size differences did not distinguish the groups. These findings demonstrate different relationships within temporal lobe structures that distinguish subjects with autism from controls. Results are discussed in terms of pathological connectivity within the temporal lobe as it relates to autism.
AB - The temporal lobe is thought to be abnormal in autism, yet standard volumetric analyses are often unrevealing when age, sex, IQ, and head size are controlled. Quantification of temporal lobe structures were obtained in male subjects with autism and controls, where subjects with head circumference (HC) defined macrocephaly were excluded, so that volume differences were not just related to the higher prevalence of macrocephaly in autism. Various statistical methods were applied to the analysis including a classification and regression tree (CART) method, a non-parametric technique that helps define patterns of relationships that may be meaningful in distinguishing temporal lobe differences between subjects with autism and age and IQ matched controls. Subjects with autism were also compared to a separate control group with reading disorder (RD), with the prediction that the temporal lobe morphometric analysis of the reading disorder controls would be more similar to that of the autism group. The CART method yielded a high specificity in classifying autism subjects from controls based on the relationship between the volume of the left fusiform gyrus (LFG) gray and white matter, the right temporal stem (RTS) and the right inferior temporal gyrus gray matter (RITG-GM). Reading disordered individuals were more similar to subjects with autism. Simple size differences did not distinguish the groups. These findings demonstrate different relationships within temporal lobe structures that distinguish subjects with autism from controls. Results are discussed in terms of pathological connectivity within the temporal lobe as it relates to autism.
KW - Autism
KW - CART analysis
KW - MRI
KW - Temporal lobe
UR - http://www.scopus.com/inward/record.url?scp=34248569902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248569902&partnerID=8YFLogxK
U2 - 10.1016/j.braindev.2006.11.006
DO - 10.1016/j.braindev.2006.11.006
M3 - Article
C2 - 17204387
AN - SCOPUS:34248569902
VL - 29
SP - 389
EP - 399
JO - Brain and Development
JF - Brain and Development
SN - 0387-7604
IS - 7
ER -