Quantitative skin color measurements in acanthosis nigricans patients: Colorimetry and diffuse reflectance spectroscopy

Bensachee Pattamadilok, Suneetha Devpura, Zain U. Syed, Oma Agbai, Pranita Vemulapalli, Marsha Henderson, Steven J. Rehse, Bassel H. Mahmoud, Henry W. Lim, Ratna Naik, Iltefat H. Hamzavi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Tristimulus colorimetry and diffuse reflectance spectroscopy (DRS) are white-light skin reflectance techniques used to measure the intensity of skin pigmentation. The tristimulus colorimeter is an instrument that measures a perceived color and the DRS instrument measures biological chromophores of the skin, including oxy- and deoxyhemoglobin, melanin and scattering. Data gathered from these tools can be used to understand morphological changes induced in skin chromophores due to conditions of the skin or their treatments. The purpose of this study was to evaluate the use of these two instruments in color measurements of acanthosis nigricans (AN) lesions. Eight patients with hyperinsulinemia and clinically diagnosable AN were seen monthly. Skin pigmentation was measured at three sites: the inner forearm, the medial aspect of the posterior neck, and anterior neck unaffected by AN. Of the three, measured tristimulus L*a*b* color parameters, the luminosity parameter L* was found to most reliably distinguish lesion from normally pigmented skin. The DRS instrument was able to characterize a lesion on the basis of the calculated melanin concentration, though melanin is a weak indicator of skin change and not a reliable measure to be used independently. Calculated oxyhemoglobin and deoxyhemoglobin concentrations were not found to be reliable indicators of AN. Tristimulus colorimetry may provide reliable methods for respectively quantifying and characterizing the objective color change in AN, while DRS may be useful in characterizing changes in skin melanin content associated with this skin condition.

Original languageEnglish (US)
Pages (from-to)213-215
Number of pages3
JournalPhotodermatology Photoimmunology and Photomedicine
Volume28
Issue number4
DOIs
StatePublished - Aug 2012
Externally publishedYes

Fingerprint

Acanthosis Nigricans
Colorimetry
Skin Pigmentation
Spectrum Analysis
Skin
Melanins
Color
Oxyhemoglobins
Neck
Hyperinsulinism
Forearm
Light

Keywords

  • Acanthosis nigricans
  • Colorimetry
  • Diffuse reflectance spectroscopy

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy
  • Immunology
  • Radiology Nuclear Medicine and imaging

Cite this

Quantitative skin color measurements in acanthosis nigricans patients : Colorimetry and diffuse reflectance spectroscopy. / Pattamadilok, Bensachee; Devpura, Suneetha; Syed, Zain U.; Agbai, Oma; Vemulapalli, Pranita; Henderson, Marsha; Rehse, Steven J.; Mahmoud, Bassel H.; Lim, Henry W.; Naik, Ratna; Hamzavi, Iltefat H.

In: Photodermatology Photoimmunology and Photomedicine, Vol. 28, No. 4, 08.2012, p. 213-215.

Research output: Contribution to journalArticle

Pattamadilok, B, Devpura, S, Syed, ZU, Agbai, O, Vemulapalli, P, Henderson, M, Rehse, SJ, Mahmoud, BH, Lim, HW, Naik, R & Hamzavi, IH 2012, 'Quantitative skin color measurements in acanthosis nigricans patients: Colorimetry and diffuse reflectance spectroscopy', Photodermatology Photoimmunology and Photomedicine, vol. 28, no. 4, pp. 213-215. https://doi.org/10.1111/j.1600-0781.2012.00663.x
Pattamadilok, Bensachee ; Devpura, Suneetha ; Syed, Zain U. ; Agbai, Oma ; Vemulapalli, Pranita ; Henderson, Marsha ; Rehse, Steven J. ; Mahmoud, Bassel H. ; Lim, Henry W. ; Naik, Ratna ; Hamzavi, Iltefat H. / Quantitative skin color measurements in acanthosis nigricans patients : Colorimetry and diffuse reflectance spectroscopy. In: Photodermatology Photoimmunology and Photomedicine. 2012 ; Vol. 28, No. 4. pp. 213-215.
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