Quantitative PET in the 2020s: A roadmap

Steven R. Meikle, Vesna Sossi, Emilie Roncali, Simon R. Cherry, Richard Banati, David Mankoff, Terry Jones, Michelle James, Julie Sutcliffe, Jinsong Ouyang, Yoann Petibon, Chao Ma, Georges El Fakhri, Suleman Surti, Joel S. Karp, Ramsey D. Badawi, Taiga Yamaya, Go Akamatsu, Georg Schramm, Ahmadreza RezaeiJohan Nuyts, Roger Fulton, André Kyme, Cristina Lois, Hasan Sari, Julie Price, Ronald Boellaard, Robert Jeraj, Dale L. Bailey, Enid Eslick, Kathy P. Willowson, Joyita Dutta

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Positron emission tomography (PET) plays an increasingly important role in research and clinical applications, catalysed by remarkable technical advances and a growing appreciation of the need for reliable, sensitive biomarkers of human function in health and disease. Over the last 30 years, a large amount of the physics and engineering effort in PET has been motivated by the dominant clinical application during that period, oncology. This has led to important developments such as PET/CT, whole-body PET, 3D PET, accelerated statistical image reconstruction, and time-of-flight PET. Despite impressive improvements in image quality as a result of these advances, the emphasis on static, semi-quantitative 'hot spot' imaging for oncologic applications has meant that the capability of PET to quantify biologically relevant parameters based on tracer kinetics has not been fully exploited. More recent advances, such as PET/MR and total-body PET, have opened up the ability to address a vast range of new research questions, from which a future expansion of applications and radiotracers appears highly likely. Many of these new applications and tracers will, at least initially, require quantitative analyses that more fully exploit the exquisite sensitivity of PET and the tracer principle on which it is based. It is also expected that they will require more sophisticated quantitative analysis methods than those that are currently available. At the same time, artificial intelligence is revolutionizing data analysis and impacting the relationship between the statistical quality of the acquired data and the information we can extract from the data. In this roadmap, leaders of the key sub-disciplines of the field identify the challenges and opportunities to be addressed over the next ten years that will enable PET to realise its full quantitative potential, initially in research laboratories and, ultimately, in clinical practice.

Original languageEnglish (US)
Article number06RM01
JournalPhysics in medicine and biology
Issue number6
StatePublished - Mar 21 2021


  • dosimetry
  • magnetic resonance imaging
  • motion correction
  • Positron emission tomography
  • quantification
  • time-of-flight PET
  • total-body PET

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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