Quantitative oxygenation venography from MRI phase

Audrey P. Fan, Berkin Bilgic, Louis Gagnon, Thomas Witzel, Himanshu Bhat, Bruce R. Rosen, Elfar Adalsteinsson

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Purpose To demonstrate acquisition and processing methods for quantitative oxygenation venograms that map in vivo oxygen saturation (SvO2) along cerebral venous vasculature. Methods Regularized quantitative susceptibility mapping (QSM) is used to reconstruct susceptibility values and estimate SvO 2 in veins. QSM with ℓ1 and ℓ2 regularization are compared in numerical simulations of vessel structures with known magnetic susceptibility. Dual-echo, flow-compensated phase images are collected in three healthy volunteers to create QSM images. Bright veins in the susceptibility maps are vectorized and used to form a three-dimensional vascular mesh, or venogram, along which to display SvO2 values from QSM. Results Quantitative oxygenation venograms that map SvO2 along brain vessels of arbitrary orientation and geometry are shown in vivo. SvO2 values in major cerebral veins lie within the normal physiological range reported by 15O positron emission tomography. SvO2 from QSM is consistent with previous MR susceptometry methods for vessel segments oriented parallel to the main magnetic field. In vessel simulations, ℓ1 regularization results in less than 10% SvO2 absolute error across all vessel tilt orientations and provides more accurate SvO2 estimation than ℓ2 regularization. Conclusion The proposed analysis of susceptibility images enables reliable mapping of quantitative SvO2 along venograms and may facilitate clinical use of venous oxygenation imaging.

Original languageEnglish (US)
Pages (from-to)149-159
Number of pages11
JournalMagnetic Resonance in Medicine
Volume72
Issue number1
DOIs
StatePublished - Jul 2014
Externally publishedYes

Keywords

  • brain oxygenation
  • quantitative susceptibility
  • venography
  • venous oxygen saturation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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