Quantitative MRI assessments of white matter in children treated for acute lymphoblastic leukemia

Wilburn E. Reddick, John O. Glass, Kathleen J. Helton, Chin-Shang Li, Ching Hon Pui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this study was to use objective quantitative MR imaging methods to prospectively assess changes in the physiological structure of white matter during the temporal evolution of leukoencephalopathy (LE) in children treated for acute lymphoblastic leukemia. The longitudinal incidence, extent (proportion of white matter affect), and intensity (elevation of T1 and T2 relaxation rates) of LE was evaluated for 44 children. A combined imaging set consisting of T1, T2, PD, and FLAIR MR images and white matter, gray matter and CSF a priori maps from a spatially normalized atlas were analyzed with a neural network segmentation based on a Kohonen Self-Organizing Map (SOM). Quantitative T1 and T2 relaxation maps were generated using a nonlinear parametric optimization procedure to fit the corresponding multi-exponential models. A Cox proportional regression was performed to estimate the effect of intravenous methotrexate (IV-MTX) exposure on the development of LE followed by a generalized linear model to predict the probability of LE in new patients. Additional T-tests of independent samples were performed to assess differences in quantitative measures of extent and intensity at four different points in therapy. Higher doses and more courses of IV-MTX placed patients at a higher risk of developing LE and were associated with more intense changes affecting more of the white matter volume; many of the changes resolved after completion of therapy. The impact of these changes on neurocognitive functioning and quality of life in survivors remains to be determined.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsA.A. Amini, A. Manduca
Pages604-613
Number of pages10
Volume5746
EditionII
DOIs
StatePublished - 2005
Externally publishedYes
EventMedical Imaging 2005 - Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 13 2005Feb 15 2005

Other

OtherMedical Imaging 2005 - Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period2/13/052/15/05

Fingerprint

Magnetic resonance imaging
Imaging techniques
Self organizing maps
Neural networks

Keywords

  • Neurotoxicity
  • Pediatric Oncology
  • Quantitative MR Imaging
  • Relaxometry
  • Segmentation
  • White Matter

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Reddick, W. E., Glass, J. O., Helton, K. J., Li, C-S., & Pui, C. H. (2005). Quantitative MRI assessments of white matter in children treated for acute lymphoblastic leukemia. In A. A. Amini, & A. Manduca (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (II ed., Vol. 5746, pp. 604-613). [70] https://doi.org/10.1117/12.594622

Quantitative MRI assessments of white matter in children treated for acute lymphoblastic leukemia. / Reddick, Wilburn E.; Glass, John O.; Helton, Kathleen J.; Li, Chin-Shang; Pui, Ching Hon.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / A.A. Amini; A. Manduca. Vol. 5746 II. ed. 2005. p. 604-613 70.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Reddick, WE, Glass, JO, Helton, KJ, Li, C-S & Pui, CH 2005, Quantitative MRI assessments of white matter in children treated for acute lymphoblastic leukemia. in AA Amini & A Manduca (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. II edn, vol. 5746, 70, pp. 604-613, Medical Imaging 2005 - Physiology, Function, and Structure from Medical Images, San Diego, CA, United States, 2/13/05. https://doi.org/10.1117/12.594622
Reddick WE, Glass JO, Helton KJ, Li C-S, Pui CH. Quantitative MRI assessments of white matter in children treated for acute lymphoblastic leukemia. In Amini AA, Manduca A, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. II ed. Vol. 5746. 2005. p. 604-613. 70 https://doi.org/10.1117/12.594622
Reddick, Wilburn E. ; Glass, John O. ; Helton, Kathleen J. ; Li, Chin-Shang ; Pui, Ching Hon. / Quantitative MRI assessments of white matter in children treated for acute lymphoblastic leukemia. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / A.A. Amini ; A. Manduca. Vol. 5746 II. ed. 2005. pp. 604-613
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