Quantitative MR-guided transient shear wave imaging for tissue elasticity assessment

Yu Liu, Jingfei Liu, Brett Z. Fite, Josquin Foiret, Jonathan K Leach, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Elastography is an efficient alternative to the traditional palpation method of assessing tissue stiffness. Magnetic resonance imaging (MRI) provides a three-dimensional (3D) high-resolution view of the surrounding anatomy during interventions. Therefore, the development of MRI-based elastographic strategies is desirable for multiple clinical applications. In this work, we developed a new transient magnetic resonance elastography (t-MRE) protocol that improved visualization of transient shear wave propagation and applied this protocol to quantify tissue elasticity in vitro using tissue-mimicking phantoms. The MRE data were cross-validated with measurements acquired under ultrasound (US) guidance and mechanical testing (MT). Following a three-pulse excitation, the t-MRE protocol was applied to visualize planar shear waves propagating 2 to 30 mm away from the excitation location. Differences in shear modulus on the order of 1 kPa were reliably detected and estimates of shear elasticity by US-based elastography and MT differed by less than 7% of the MT gold standard value. Moreover, biologically-relevant inclusions were detected in tissue-mimicking phantoms and mapped in 3D by t-MRE.

Original languageEnglish (US)
Title of host publication2016 IEEE International Ultrasonics Symposium, IUS 2016
PublisherIEEE Computer Society
Volume2016-November
ISBN (Electronic)9781467398978
DOIs
StatePublished - Nov 1 2016
Event2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France
Duration: Sep 18 2016Sep 21 2016

Other

Other2016 IEEE International Ultrasonics Symposium, IUS 2016
CountryFrance
CityTours
Period9/18/169/21/16

Fingerprint

S waves
magnetic resonance
elastic properties
shear
anatomy
excitation
wave propagation
stiffness
inclusions
high resolution
estimates
pulses

Keywords

  • Magnetic Resonance Elastography (MRE)
  • Magnetic Resonance Imaging (MRI)
  • Mechanical Test (MT)
  • Transient Shear Wave

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Liu, Y., Liu, J., Fite, B. Z., Foiret, J., Leach, J. K., & Ferrara, K. W. (2016). Quantitative MR-guided transient shear wave imaging for tissue elasticity assessment. In 2016 IEEE International Ultrasonics Symposium, IUS 2016 (Vol. 2016-November). [7728857] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2016.7728857

Quantitative MR-guided transient shear wave imaging for tissue elasticity assessment. / Liu, Yu; Liu, Jingfei; Fite, Brett Z.; Foiret, Josquin; Leach, Jonathan K; Ferrara, Katherine W.

2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November IEEE Computer Society, 2016. 7728857.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liu, Y, Liu, J, Fite, BZ, Foiret, J, Leach, JK & Ferrara, KW 2016, Quantitative MR-guided transient shear wave imaging for tissue elasticity assessment. in 2016 IEEE International Ultrasonics Symposium, IUS 2016. vol. 2016-November, 7728857, IEEE Computer Society, 2016 IEEE International Ultrasonics Symposium, IUS 2016, Tours, France, 9/18/16. https://doi.org/10.1109/ULTSYM.2016.7728857
Liu Y, Liu J, Fite BZ, Foiret J, Leach JK, Ferrara KW. Quantitative MR-guided transient shear wave imaging for tissue elasticity assessment. In 2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November. IEEE Computer Society. 2016. 7728857 https://doi.org/10.1109/ULTSYM.2016.7728857
Liu, Yu ; Liu, Jingfei ; Fite, Brett Z. ; Foiret, Josquin ; Leach, Jonathan K ; Ferrara, Katherine W. / Quantitative MR-guided transient shear wave imaging for tissue elasticity assessment. 2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November IEEE Computer Society, 2016.
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