Abstract
Elastography is an efficient alternative to the traditional palpation method of assessing tissue stiffness. Magnetic resonance imaging (MRI) provides a three-dimensional (3D) high-resolution view of the surrounding anatomy during interventions. Therefore, the development of MRI-based elastographic strategies is desirable for multiple clinical applications. In this work, we developed a new transient magnetic resonance elastography (t-MRE) protocol that improved visualization of transient shear wave propagation and applied this protocol to quantify tissue elasticity in vitro using tissue-mimicking phantoms. The MRE data were cross-validated with measurements acquired under ultrasound (US) guidance and mechanical testing (MT). Following a three-pulse excitation, the t-MRE protocol was applied to visualize planar shear waves propagating 2 to 30 mm away from the excitation location. Differences in shear modulus on the order of 1 kPa were reliably detected and estimates of shear elasticity by US-based elastography and MT differed by less than 7% of the MT gold standard value. Moreover, biologically-relevant inclusions were detected in tissue-mimicking phantoms and mapped in 3D by t-MRE.
| Original language | English (US) |
|---|---|
| Title of host publication | 2016 IEEE International Ultrasonics Symposium, IUS 2016 |
| Publisher | IEEE Computer Society |
| Volume | 2016-November |
| ISBN (Electronic) | 9781467398978 |
| DOIs | |
| State | Published - Nov 1 2016 |
| Event | 2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France Duration: Sep 18 2016 → Sep 21 2016 |
Other
| Other | 2016 IEEE International Ultrasonics Symposium, IUS 2016 |
|---|---|
| Country | France |
| City | Tours |
| Period | 9/18/16 → 9/21/16 |
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Keywords
- Magnetic Resonance Elastography (MRE)
- Magnetic Resonance Imaging (MRI)
- Mechanical Test (MT)
- Transient Shear Wave
ASJC Scopus subject areas
- Acoustics and Ultrasonics
Cite this
Quantitative MR-guided transient shear wave imaging for tissue elasticity assessment. / Liu, Yu; Liu, Jingfei; Fite, Brett Z.; Foiret, Josquin; Leach, Jonathan K; Ferrara, Katherine W.
2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November IEEE Computer Society, 2016. 7728857.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Quantitative MR-guided transient shear wave imaging for tissue elasticity assessment
AU - Liu, Yu
AU - Liu, Jingfei
AU - Fite, Brett Z.
AU - Foiret, Josquin
AU - Leach, Jonathan K
AU - Ferrara, Katherine W.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Elastography is an efficient alternative to the traditional palpation method of assessing tissue stiffness. Magnetic resonance imaging (MRI) provides a three-dimensional (3D) high-resolution view of the surrounding anatomy during interventions. Therefore, the development of MRI-based elastographic strategies is desirable for multiple clinical applications. In this work, we developed a new transient magnetic resonance elastography (t-MRE) protocol that improved visualization of transient shear wave propagation and applied this protocol to quantify tissue elasticity in vitro using tissue-mimicking phantoms. The MRE data were cross-validated with measurements acquired under ultrasound (US) guidance and mechanical testing (MT). Following a three-pulse excitation, the t-MRE protocol was applied to visualize planar shear waves propagating 2 to 30 mm away from the excitation location. Differences in shear modulus on the order of 1 kPa were reliably detected and estimates of shear elasticity by US-based elastography and MT differed by less than 7% of the MT gold standard value. Moreover, biologically-relevant inclusions were detected in tissue-mimicking phantoms and mapped in 3D by t-MRE.
AB - Elastography is an efficient alternative to the traditional palpation method of assessing tissue stiffness. Magnetic resonance imaging (MRI) provides a three-dimensional (3D) high-resolution view of the surrounding anatomy during interventions. Therefore, the development of MRI-based elastographic strategies is desirable for multiple clinical applications. In this work, we developed a new transient magnetic resonance elastography (t-MRE) protocol that improved visualization of transient shear wave propagation and applied this protocol to quantify tissue elasticity in vitro using tissue-mimicking phantoms. The MRE data were cross-validated with measurements acquired under ultrasound (US) guidance and mechanical testing (MT). Following a three-pulse excitation, the t-MRE protocol was applied to visualize planar shear waves propagating 2 to 30 mm away from the excitation location. Differences in shear modulus on the order of 1 kPa were reliably detected and estimates of shear elasticity by US-based elastography and MT differed by less than 7% of the MT gold standard value. Moreover, biologically-relevant inclusions were detected in tissue-mimicking phantoms and mapped in 3D by t-MRE.
KW - Magnetic Resonance Elastography (MRE)
KW - Magnetic Resonance Imaging (MRI)
KW - Mechanical Test (MT)
KW - Transient Shear Wave
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UR - http://www.scopus.com/inward/citedby.url?scp=84996602339&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2016.7728857
DO - 10.1109/ULTSYM.2016.7728857
M3 - Conference contribution
VL - 2016-November
BT - 2016 IEEE International Ultrasonics Symposium, IUS 2016
PB - IEEE Computer Society
ER -